Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway‐Mediated Apoptosis and …

T Zhang, W Sun, L Wang, H Zhang… - Journal of Diabetes …, 2023 - Wiley Online Library
Diabetic nephropathy (DN) is a metabolic disease wherein chronic hyperglycemia triggers
various renal cell dysfunctions, eventually leading to progressive kidney failure. Rosa …

Polysaccharides from Liriopes Radix ameliorate streptozotocin-induced type I diabetic nephropathy via regulating NF-κB and p38 MAPK signaling pathways

HJ Lu, TF Tzeng, SS Liou, SD Lin, MC Wu… - BMC complementary and …, 2014 - Springer
Abstract Background The polysaccharides from Liriopes Radix (PSLR) has been indicated
to ameliorate insulin signaling transduction and glucose metabolism. We aimed to …

Kidney tea [Orthosiphon aristatus (Blume) Miq.] improves diabetic nephropathy via regulating gut microbiota and ferroptosis

Z Zhou, H Niu, M Bian, C Zhu - Frontiers in Pharmacology, 2024 - frontiersin.org
Introduction Diabetic nephropathy (DN) is the leading cause of end-stage renal disease.
Due to its complex pathogenesis, new therapeutic agents are urgently needed. Orthosiphon …

Beneficial effect of lycopene on anti-diabetic nephropathy through diminishing inflammatory response and oxidative stress

Y Guo, Y Liu, Y Wang - Food & function, 2015 - pubs.rsc.org
Lycopene is widely used for nutritional supplementation, but the potential benefits in diabetic
nephropathy (DN) remains unknown. This study aimed to highlight the therapeutic prospect …

Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice

D Tang, WJ He, ZT Zhang, JJ Shi, X Wang, WT Gu… - Phytomedicine, 2022 - Elsevier
Background Diabetic nephropathy (DN) is a severe diabetic complication that is the principal
cause of end-stage kidney disease worldwide. Huang-Lian-Jie-Du Decoction (HLJDD) is …

In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting …

B Hou, P Ma, X Yang, X Zhao, L Zhang, Y Zhao… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Puerarin (PUR) isolated from the root of Pueraria lobata
(Willd.) Ohwi is considered as one of the main medicines to alleviate asthenic splenonephro …

Hong Guo ginseng Guo (HGGG) Protects against kidney injury in Diabetic Nephropathy by Inhibiting NLRP3 Inflammasome and Regulating Intestinal Flora

S Pan, S Jiang, R Li, B Tian, C Huang, R Wang, Y Li… - Phytomedicine, 2024 - Elsevier
Background Diabetic nephropathy (DN) is one of the most serious complications of diabetes
which leads to end-stage renal failure and approximately one-third of patients need dialysis …

Renal protective effect of Rosa laevigata Michx. by the inhibition of oxidative stress in streptozotocin-induced diabetic rats

Y Zhou, Q Liao, Y Luo, Z Qing… - Molecular medicine …, 2012 - spandidos-publications.com
Diabetic nephropathy (DN) is a long-term complication of diabetic mellitus. Numerous
reports have suggested that oxidative stress is defined as the excessive production of …

Jian‐Pi‐Gu‐Shen‐Hua‐Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis

S Lv, L Fan, X Chen, X Su, L Dong… - Journal of Diabetes …, 2024 - Wiley Online Library
Background. Diabetic nephropathy (DN), one of the most frequent complications of diabetes
mellitus, is a leading cause of end‐stage renal disease. However, the current treatment …

Molecular mechanistic pathways targeted by natural compounds in the prevention and treatment of diabetic kidney disease

K Zhou, X Zi, J Song, Q Zhao, J Liu, H Bao, L Li - Molecules, 2022 - mdpi.com
Diabetic kidney disease (DKD) is one of the most common complications of diabetes, and its
prevalence is still growing rapidly. However, the efficient therapies for this kidney disease …