Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide
K Messaoudi, A Clavreul, F Lagarce - Drug discovery today, 2015 - Elsevier
Highlights•Temozolomide resistance can be induced by glioblastoma cells.•Resistance to
temozolomide is caused by multiple mechanisms.•Different resistance pathways exist in …
temozolomide is caused by multiple mechanisms.•Different resistance pathways exist in …
Molecular mechanisms of temozolomide resistance in glioblastoma multiforme
TCA Johannessen, R Bjerkvig - Expert review of anticancer …, 2012 - Taylor & Francis
Glioblastoma multiforme (GBM; WHO astrocytoma grade IV) is considered incurable owing
to its inherently profound resistance towards current standards of therapy. Considerable …
to its inherently profound resistance towards current standards of therapy. Considerable …
Elucidating the mechanisms of Temozolomide resistance in gliomas and the strategies to overcome the resistance.
Temozolomide (TMZ) is a first-choice alkylating agent inducted as a gold standard therapy
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …
Glioblastoma vs temozolomide: can the red queen race be won?
A Arora, K Somasundaram - Cancer biology & therapy, 2019 - Taylor & Francis
Glioblastoma is the most invasive form of brain tumor. Although temozolomide
chemotherapy has been shown to significantly improve survival in patients with GBM, this …
chemotherapy has been shown to significantly improve survival in patients with GBM, this …
[HTML][HTML] Temozolomide resistance in glioblastoma multiforme
SY Lee - Genes & diseases, 2016 - Elsevier
Temozolomide (TMZ) is an oral alkylating agent used to treat glioblastoma multiforme (GBM)
and astrocytomas. However, at least 50% of TMZ treated patients do not respond to TMZ …
and astrocytomas. However, at least 50% of TMZ treated patients do not respond to TMZ …
Potential strategies overcoming the temozolomide resistance for glioblastoma
S Jiapaer, T Furuta, S Tanaka, T Kitabayashi… - Neurologia medico …, 2018 - jstage.jst.go.jp
Glioblastoma (GBM) is a highly malignant type of primary brain tumor with a high mortality
rate. Although the current standard therapy consists of surgery followed by radiation and …
rate. Although the current standard therapy consists of surgery followed by radiation and …
[HTML][HTML] Mechanisms of temozolomide resistance in glioblastoma-a comprehensive review
N Singh, A Miner, L Hennis, S Mittal - Cancer drug resistance, 2021 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …
exceedingly low median overall survival of only 15 months. Current standard-of-care for …
Temozolomide resistance in glioblastoma cell lines: implication of MGMT, MMR, P-glycoprotein and CD133 expression
Background The use of temozolomide (TMZ) has improved the prognosis for glioblastoma
multiforme patients. However, TMZ resistance may be one of the main reasons why …
multiforme patients. However, TMZ resistance may be one of the main reasons why …
Temozolomide: mechanisms of action, repair and resistance
J Zhang, M FG Stevens… - Current molecular …, 2012 - ingentaconnect.com
Glioblastoma multiforme is the most common aggressive adult primary tumour of the central
nervous system. Treatment includes surgery, radiotherapy and adjuvant temozolomide …
nervous system. Treatment includes surgery, radiotherapy and adjuvant temozolomide …
Strategies of temozolomide in future glioblastoma treatment
CY Lee - OncoTargets and therapy, 2017 - Taylor & Francis
Glioblastoma multiforme (GBM) may be one of the most challenging brain tumors to treat, as
patients generally do not live more than 2 years. This review aimed to give a timely review of …
patients generally do not live more than 2 years. This review aimed to give a timely review of …
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