The purpose of this work is to study the effect of smilagenin on the mRNA stability of
muscarinic receptor subtype 1 (M1; m1 mRNA) in aged rat brains and its significance in …

The purpose of this paper is to study the effect of smilagenin (SMI)(PYM50028), a sapogenin
compound originally identified from Chinese medicinal herb, on dopamine neurons and …

The development of drugs that attenuate neurodegeneration is important for the treatment of
Alzheimer's disease (AD). We previously found that smilagenin (SMI), a steroidal sapogenin …

This research was done to make the effective prescription and cope with various senile
dementia. Sprague-Dawley rats were injured by ibotenic acid to make a damage on learning …

The purpose of this paper is to study the basic pharmacological action of sarsasapogenin, a
sapogenin from the Chinese medicinal herb Rhizoma Anemarrhenae,(abbreviated as ZMS …

Background Smilagenin (SMI) is a lipid-soluble steroidal sapogenin, extracted from
traditional Chinses medicinal herbs Radix Asparagi, which is extracted from the dry root of …

Musashi RNA-binding proteins (MSIs) retain a pivotal role in stem cell maintenance,
tumorigenesis, and nervous system development. Recently, we showed in C. elegans that …

J. Neurochem.(2012) 121, 77–98. Abstract Impairment of cognitive functions including
hippocampus‐dependent spatial learning and memory affects nearly half of the aged …

Memantine, an uncompetitive N-methyl-D-aspartate receptor antagonist, is used for
treatment of patients with Alzheimer's disease. The mechanisms of memantine in relieving …

An established senescence-accelerated model mouse strain, SAMP8, shows the
deterioration of learning and memory compared with a normal control strain, SAMR1. d …