Pathogenesis and novel treatment options for non-alcoholic steatohepatitis

VWS Wong, S Chitturi, GLH Wong, J Yu… - The Lancet …, 2016 - thelancet.com
Non-alcoholic fatty liver disease affects 20–40% of the population. Its active form, non-
alcoholic steatohepatitis (NASH), is characterised by hepatocyte injury, liver inflammation …

[HTML][HTML] Drugs for non-alcoholic steatohepatitis (NASH): quest for the holy grail

M Sharma, M Premkumar, AV Kulkarni… - Journal of clinical and …, 2021 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a global epidemic that is likely to become the
most common cause of chronic liver disease in the next decade, worldwide. Though …

Nonalcoholic steatohepatitis (NASH) and hepatic fibrosis: emerging therapies

J Wattacheril, D Issa, A Sanyal - Annual review of pharmacology …, 2018 - annualreviews.org
Nonalcoholic fatty liver disease remains a major cause of liver-related morbidity and
mortality worldwide. It is a complex disease associated with obesity, diabetes, and …

Perspectives on treatment for nonalcoholic steatohepatitis

G Lassailly, R Caiazzo, F Pattou, P Mathurin - Gastroenterology, 2016 - Elsevier
It is important to provide treatment to patients with nonalcoholic steatohepatitis (NASH)
because one third of patients with the metabolic syndrome die of liver disease. Basic …

Current management of non‐alcoholic steatohepatitis

MD Muthiah, AJ Sanyal - Liver International, 2020 - Wiley Online Library
Non‐alcoholic steatohepatitis (NASH) is the most common cause of liver disease in Western
populations, and its prevalence is increasing rapidly. It is part of a multisystem disease …

Therapies in non‐alcoholic steatohepatitis (NASH)

AM Oseini, AJ Sanyal - Liver International, 2017 - Wiley Online Library
The hallmark of non‐alcoholic fatty liver disease (NAFLD) is excessive fatty accumulation in
the hepatocytes, which may be an isolated event (non‐alcoholic fatty liver, NAFL) or …

A review of current and upcoming treatment modalities in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

S Ganguli, P DeLeeuw… - … medicine: evidence and …, 2019 - Taylor & Francis
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
in the West. Non-alcoholic steatohepatitis (NASH) is the progressive form of NAFLD and can …

Therapeutic pipeline in nonalcoholic steatohepatitis

R Vuppalanchi, M Noureddin, N Alkhouri… - Nature reviews …, 2021 - nature.com
Our understanding of nonalcoholic fatty liver disease pathophysiology continues to advance
rapidly. Accordingly, the field has moved from describing the clinical phenotype through the …

Emerging and future therapies for nonalcoholic steatohepatitis in adults

G Mintziori, SA Polyzos - Expert Opinion on Pharmacotherapy, 2016 - Taylor & Francis
Introduction: Nonalcoholic steatohepatitis (NASH) is a disease of increasing prevalence with
morbidity and mortality closely related to cardiovascular disease, malignancies and …

Non-alcoholic steatohepatitis pathogenesis, diagnosis, and treatment

B Zhu, SL Chan, J Li, K Li, H Wu, K Cui… - Frontiers in …, 2021 - frontiersin.org
There has been a rise in the prevalence of non-alcohol fatty liver disease (NAFLD) due to
the popularity of western diets and sedentary lifestyles. One quarter of NAFLD patients is …