Research on maternal-fetal epigenetic programming argues that adverse exposures to the
intrauterine environment can have long-term effects on adult morbidity and mortality …

Background Preterm birth confers a high risk of adverse long term health outcomes for
survivors, yet the underlying molecular mechanisms are unclear. We hypothesized that …

Background Chronic psychological stress is associated with accelerated aging and
increased risk for aging-related diseases, but the underlying molecular mechanisms are …

The accumulation of everyday exposures can impact health across the life course, but our
understanding of such exposures is impeded by our ability to delineate the relationship …

Epigenetic clocks have been widely used to predict disease risk in multiple tissues or cells.
Their success as a measure of biological ageing has prompted research on the connection …

A growing body of evidence suggests that the risk of development and progression of a
variety of human chronic diseases depends on epigenetic modifications triggered by …

Adverse childhood experiences (ACEs) increase risk for depression at subsequent ages
and have been linked to accelerated biological aging. We hypothesize that accelerated …

Aging is the single most important risk factor for diseases that are currently the leading
causes of morbidity and mortality. However, there is considerable inter-individual variability …

Severe or chronic stress and trauma can have a detrimental impact on health. Evidence
suggests that early-life adversity can become biologically embedded and has the potential …

Background Past research has linked low socio-economic status (SES) to inflammation,
metabolic dysregulation, and various chronic and age-related diseases such as type 2 …