[HTML][HTML] Molecular mechanisms of treatment resistance in glioblastoma

A Ou, WKA Yung, N Majd - International journal of molecular sciences, 2020 - mdpi.com
Glioblastoma is the most common malignant primary brain tumor in adults and is almost
invariably fatal. Despite our growing understanding of the various mechanisms underlying …

[HTML][HTML] The many facets of therapy resistance and tumor recurrence in glioblastoma

A Goenka, D Tiek, X Song, T Huang, B Hu, SY Cheng - Cells, 2021 - mdpi.com
Glioblastoma (GBM) is the most lethal type of primary brain cancer. Standard care using
chemo-and radio-therapy modestly increases the overall survival of patients; however …

[HTML][HTML] Glioblastoma chemoresistance: the double play by microenvironment and blood-brain barrier

M Da Ros, V De Gregorio, AL Iorio, L Giunti… - International journal of …, 2018 - mdpi.com
For glioblastoma, the tumor microenvironment (TME) is pivotal to support tumor progression
and therapeutic resistance. TME consists of several types of stromal, endothelial and …

[HTML][HTML] Critical view of novel treatment strategies for glioblastoma: failure and success of resistance mechanisms by glioblastoma cells

T Burster, R Traut, Z Yermekkyzy, K Mayer… - Frontiers in Cell and …, 2021 - frontiersin.org
According to the invasive nature of glioblastoma, which is the most common form of
malignant brain tumor, the standard care by surgery, chemo-and radiotherapy is particularly …

Mechanisms of immunotherapy resistance: lessons from glioblastoma

CM Jackson, J Choi, M Lim - Nature immunology, 2019 - nature.com
Glioblastoma (GBM) is the deadliest form of brain cancer, with a median survival of less than
2 years despite surgical resection, radiation, and chemotherapy. GBM's rapid progression …

[HTML][HTML] Molecular mechanisms of drug resistance in glioblastoma

MA Dymova, EV Kuligina, VA Richter - International journal of molecular …, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly
resistant to conventional radiation and chemotherapy, and is not amenable to effective …

Challenges in the treatment of glioblastoma: multisystem mechanisms of therapeutic resistance

EK Noch, R Ramakrishna, R Magge - World neurosurgery, 2018 - Elsevier
Glioblastoma is one of the most lethal human cancers, with poor survival despite surgery,
radiation treatment, and chemotherapy. Advances in the treatment of this type of brain tumor …

Cellular and molecular mechanisms of glioblastoma malignancy: Implications in resistance and therapeutic strategies

J Balça-Silva, D Matias, A do Carmo… - Seminars in cancer …, 2019 - Elsevier
Glioblastoma (GB) is the more frequent and malignant brain tumour. In spite of all efforts, the
median overall survival of GB patients remains approximately 15 months under therapy. The …

Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance

W Wu, JL Klockow, M Zhang, F Lafortune… - Pharmacological …, 2021 - Elsevier
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …

[HTML][HTML] Pathogenetic features and current management of glioblastoma

HM Nguyen, K Guz-Montgomery, DB Lowe, D Saha - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma (GBM) is the most common form of primary malignant brain
tumor with a devastatingly poor prognosis. Tumor heterogeneity (cellular, molecular and …