Abstract P53-MDM2 protein-protein interaction (PPI) is one of the most well-established
studied which is involved in human cancer. Most importantly, cell cycle and apoptosis are …

In most types of cancer, overexpression of murine double minute 2 (MDM2) often leads to
inactivation of p53. The crystal structure of MDM2, with a 109-residue amino-terminal …

Abstract P53-MDM2 protein-protein interaction (PPI) is one of the most crucial and
intensively studied PPIs involved in human cancer. Importantly, cell cycle and apoptosis are …

Background: Cancer is characterized by overexpression of p53 associated proteins, which
down-regulate P53 signaling pathway. In cancer therapy, p53 activity can be restored by …

P53 is a tumor suppressor gene with a well established role in causation of different human
cancers. The p53-MDM2 interactions have become the cornerstone of intensive cancer …

Transcription factor p53, also known as tumor suppressor protein. Encoded by the TP53
gene, the guardian of genome p53 regulates many gene pathways. Nevertheless, the …

Background: Cancer is a major global health problem with high mortality rate. Most of the
clinically used anticancer agents induce apoptosis through genotoxic stress at various …

Cancer is a major global health issue that has a high mortality rate. p53, which functions as
a tumor suppressor, is critical in preventing tumor development by regulating the cell cycle …

The interaction between the tumor suppressor protein p53 and its negative regulator, the
MDM2 oncogenic protein, has gained significant attention in cancer drug discovery. In this …

Hinokiflavone (HF), a natural biflavonoid that possesses various biological activities, has
reported that HF could be a pre-mRNA splicing modulator, whereas its underlying …