Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication

M Ito, Y Fujita, A Shinohara - DNA repair, 2023 - Elsevier
RAD51 recombinase plays a central role in homologous recombination (HR) by forming a
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …

[HTML][HTML] Putting together and taking apart: assembly and disassembly of the Rad51 nucleoprotein filament in DNA repair and genome stability

T Andriuskevicius, O Kotenko, S Makovets - Cell Stress, 2018 - ncbi.nlm.nih.gov
Homologous recombination is a key mechanism providing both genome stability and
genetic diversity in all living organisms. Recombinases play a central role in this pathway …

Rad51/Dmc1 paralogs and mediators oppose DNA helicases to limit hybrid DNA formation and promote crossovers during meiotic recombination

A Lorenz, A Mehats, F Osman… - Nucleic Acids …, 2014 - academic.oup.com
During meiosis programmed DNA double-strand breaks (DSBs) are repaired by
homologous recombination using the sister chromatid or the homologous chromosome …

Rad51 filament dynamics and its antagonistic modulators

A Carver, X Zhang - Seminars in cell & developmental biology, 2021 - Elsevier
Rad51 recombinase is the central player in homologous recombination, the faithful repair
pathway for double-strand breaks and key event during meiosis. Rad51 forms nucleoprotein …

Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication

SK Godin, MR Sullivan… - Biochemistry and Cell …, 2016 - cdnsciencepub.com
In this review we focus on new insights that challenge our understanding of homologous
recombination (HR) and Rad51 regulation. Recent advances using high-resolution …

Observation and analysis of RAD51 nucleation dynamics at single-monomer resolution

S Subramanyam, CD Kinz-Thompson… - Methods in …, 2018 - Elsevier
Human RAD51 promotes accurate DNA repair by homologous recombination and is
involved in protection and repair of damaged DNA replication forks. The active species of …

Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filament

AV Mazin, CJ Bornarth, JA Solinger, WD Heyer… - Molecular cell, 2000 - cell.com
Rad51 and Rad54 proteins are important for the repair of double-stranded DNA (dsDNA)
breaks by homologous recombination in eukaryotes. Rad51 assembles on single-stranded …

A novel function of Rad54 protein: stabilization of the Rad51 nucleoprotein filament

AV Mazin, AA Alexeev, SC Kowalczykowski - Journal of Biological …, 2003 - ASBMB
Homologous recombination is important for the repair of double-stranded DNA breaks in all
organisms. Rad51 and Rad54 proteins are two key components of the homologous …

RADX controls RAD51 filament dynamics to regulate replication fork stability

MB Adolph, TM Mohamed, S Balakrishnan, C Xue… - Molecular cell, 2021 - cell.com
The RAD51 recombinase forms nucleoprotein filaments to promote double-strand break
repair, replication fork reversal, and fork stabilization. The stability of these filaments is highly …

Analysis of mouse Rad54 expression and its implications for homologous recombination

J Essers, RW Hendriks, J Wesoly, CEMT Beerens… - DNA repair, 2002 - Elsevier
Homologous recombination is one of the major pathways for repair of DNA double-strand
breaks (DSBs). Important proteins in this pathway are Rad51 and Rad54. Rad51 forms a …