Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …

Yes-associated protein (YAP) and its paralog WW domain containing transcription regulator
1 (TAZ) are important regulators of multiple cellular functions such as proliferation …

The evolution of a solid tumor is fueled by genetic aberrations. Yet, the tumor environment
often dominates over the effects of genetics: normal tissues have powerful tumor …

ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …

YAP and TAZ are intracellular messengers communicating multiple interacting extracellular
biophysical and biochemical cues to the transcription apparatus in the nucleus and back to …

YAP and TAZ are ubiquitously expressed homologous proteins originally identified as
penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining …

Most cancer cells are exposed to altered extracellular environments, such as an increase in
extracellular matrix (ECM) stiffness and soluble signals consisting of growth factors and …

The Hippo pathway, initially identified through screenings for mutant tumor suppressors in
Drosophila, is an evolutionarily conserved signaling pathway that controls organ size by …

Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is
both a cause and consequence of fibroblast activation. However, the molecular mechanisms …

The YAP/TAZ family of transcriptional co‐activators drives cell proliferation in epithelial
tissues and cancers. Yet, how YAP and TAZ are physiologically regulated remains unclear …