[HTML][HTML] A single-cell atlas of chromatin accessibility in the human genome
Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
A human cell atlas of fetal chromatin accessibility
INTRODUCTION In recent years, the single-cell genomics field has made incredible
progress toward disentangling the cellular heterogeneity of human tissues. However, the …
progress toward disentangling the cellular heterogeneity of human tissues. However, the …
A single-cell atlas of in vivo mammalian chromatin accessibility
We applied a combinatorial indexing assay, sci-ATAC-seq, to profile genome-wide
chromatin accessibility in∼ 100,000 single cells from 13 adult mouse tissues. We identify 85 …
chromatin accessibility in∼ 100,000 single cells from 13 adult mouse tissues. We identify 85 …
[HTML][HTML] ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis
The advent of single-cell chromatin accessibility profiling has accelerated the ability to map
gene regulatory landscapes but has outpaced the development of scalable software to …
gene regulatory landscapes but has outpaced the development of scalable software to …
Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility
Joint profiling of transcriptome and chromatin accessibility within single cells allows for the
deconstruction of the complex relationship between transcriptional states and upstream …
deconstruction of the complex relationship between transcriptional states and upstream …
A human cell atlas of fetal gene expression
INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …
set out to generate single-cell atlases of both gene expression (this study) and chromatin …
Multiplex single-cell profiling of chromatin accessibility by combinatorial cellular indexing
Technical advances have enabled the collection of genome and transcriptome data sets
with single-cell resolution. However, single-cell characterization of the epigenome has …
with single-cell resolution. However, single-cell characterization of the epigenome has …
A compendium of promoter-centered long-range chromatin interactions in the human genome
A large number of putative cis-regulatory sequences have been annotated in the human
genome, but the genes they control remain poorly defined. To bridge this gap, we generate …
genome, but the genes they control remain poorly defined. To bridge this gap, we generate …
Interplay between chromatin state, regulator binding, and regulatory motifs in six human cell types
The regions bound by sequence-specific transcription factors can be highly variable across
different cell types despite the static nature of the underlying genome sequence. This has …
different cell types despite the static nature of the underlying genome sequence. This has …
Integrative annotation of chromatin elements from ENCODE data
The ENCODE Project has generated a wealth of experimental information mapping diverse
chromatin properties in several human cell lines. Although each such data track is …
chromatin properties in several human cell lines. Although each such data track is …