[HTML][HTML] Molecular mechanisms and potential new therapeutic drugs for liver fibrosis
FD Wang, J Zhou, EQ Chen - Frontiers in pharmacology, 2022 - frontiersin.org
Liver fibrosis is the pathological process of excessive extracellular matrix deposition after
liver injury and is a precursor to cirrhosis, hepatocellular carcinoma (HCC). It is essentially a …
liver injury and is a precursor to cirrhosis, hepatocellular carcinoma (HCC). It is essentially a …
[HTML][HTML] Promising therapy candidates for liver fibrosis
Liver fibrosis is a wound-healing process in response to repeated and chronic injury to
hepatocytes and/or cholangiocytes. Ongoing hepatocyte apoptosis or necrosis lead to …
hepatocytes and/or cholangiocytes. Ongoing hepatocyte apoptosis or necrosis lead to …
[HTML][HTML] Liver fibrosis: mechanistic concepts and therapeutic perspectives
N Roehlen, E Crouchet, TF Baumert - Cells, 2020 - mdpi.com
Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …
Emerging therapeutic targets for the treatment of hepatic fibrosis
P Fagone, K Mangano, A Pesce, TR Portale… - Drug Discovery …, 2016 - Elsevier
Highlights•Liver fibrosis is an important health problem associated to morbility and
mortality.•Extensive data have provided knowledge of the major key cellular and molecular …
mortality.•Extensive data have provided knowledge of the major key cellular and molecular …
Hepatic fibrosis: molecular mechanisms and drug targets
S Lotersztajn, B Julien, F Teixeira-Clerc… - Annu. Rev …, 2005 - annualreviews.org
▪ Abstract Liver fibrosis is the common response to chronic liver injury, ultimately leading to
cirrhosis and its complications, portal hypertension, liver failure, and hepatocellular …
cirrhosis and its complications, portal hypertension, liver failure, and hepatocellular …
[HTML][HTML] Liver fibrosis: therapeutic targets and advances in drug therapy
Z Tan, H Sun, T Xue, C Gan, H Liu, Y Xie… - Frontiers in cell and …, 2021 - frontiersin.org
Liver fibrosis is an abnormal wound repair response caused by a variety of chronic liver
injuries, which is characterized by over-deposition of diffuse extracellular matrix (ECM) and …
injuries, which is characterized by over-deposition of diffuse extracellular matrix (ECM) and …
[HTML][HTML] Anti-fibrotic treatments for chronic liver diseases: The present and the future
N Odagiri, T Matsubara, M Sato-Matsubara… - Clinical and …, 2021 - ncbi.nlm.nih.gov
Liver fibrosis reflects tissue scarring in the liver due to the accumulation of excessive
extracellular matrix in response to chronically persistent liver injury. Hepatocyte cell death …
extracellular matrix in response to chronically persistent liver injury. Hepatocyte cell death …
[HTML][HTML] Pathophysiology and treatment options for hepatic fibrosis: can it be completely cured?
A Khanam, PG Saleeb, S Kottilil - Cells, 2021 - mdpi.com
Hepatic fibrosis is a dynamic process that occurs as a wound healing response against liver
injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells …
injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells …
[HTML][HTML] The molecular mechanisms of liver fibrosis and its potential therapy in application
D Zhang, Y Zhang, B Sun - International Journal of Molecular Sciences, 2022 - mdpi.com
Liver fibrosis results from repeated and persistent liver damage. It can start with hepatocyte
injury and advance to inflammation, which recruits and activates additional liver immune …
injury and advance to inflammation, which recruits and activates additional liver immune …
[HTML][HTML] Cellular mechanisms of liver fibrosis
The liver is a central organ in the human body, coordinating several key metabolic roles. The
structure of the liver which consists of the distinctive arrangement of hepatocytes, hepatic …
structure of the liver which consists of the distinctive arrangement of hepatocytes, hepatic …
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