Heart failure is a complex syndrome of numerous dysfunctional components which converge
to cause chronic progressive failure of ventricular contractile function and maintenance of …

Heart failure is a growing health burden worldwide characterized by alterations in excitation-
contraction coupling, cardiac energetic deficit and oxidative stress. While current treatments …

It has become common sense that the failing heart is an “engine out of fuel”. However,
undisputable evidence that, indeed, the failing heart is limited by insufficient ATP supply is …

Heart failure (HF) is a syndrome causing a huge burden in morbidity and mortality
worldwide. Current medical therapies for HF are aimed at suppressing the neurohormonal …

Advances in cardiovascular research have identified oxidative stress as an important
pathophysiological pathway in the development and progression of heart failure. Oxidative …

Despite advances in treatment, chronic congestive heart failure carries a poor prognosis and
remains a leading cause of cardiovascular death. Accumulating evidence suggests that …

Elderly people insidiously manifest the symptoms of heart failure, such as dyspnea and/or
physical disabilities in an age-dependent manner. Although previous studies suggested that …

A constant supply of oxygen is indispensable for cardiac viability and function. However, the
role of oxygen and oxygen-associated processes in the heart is complex, and they and can …

Heart failure and many of the conditions that predispose to heart failure are associated with
oxidative stress. This is considered to be important in the pathophysiology of the condition …

Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative
to antioxidant defense, has been shown to play an important role in the pathophysiology of …