Latent infection with Mycobacterium tuberculosis (LTBI) is defined by the presence of M.
tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using …

Nearly a third of the world's population is estimated to be infected with Mycobacterium
tuberculosis. This enormous pool of latently infected individuals poses a major hurdle for …

The identification of individuals with latent tuberculosis infection (LTBI) is useful for both
fundamental understanding of the pathogenesis of disease and for clinical and public health …

Objective Accurate and timely diagnosis of tuberculosis (TB) is essential to control the global
pandemic. Currently available immunodiagnostic tests cannot discriminate between latent …

Rationale: Current immunodiagnostic tests for tuberculosis (TB), including the tuberculin
skin test and IFN-γ release assay (IGRA), have significant limitations, which include their …

Tuberculosis control relies on the identification and preventive treatment of individuals who
are latently infected with Mycobacterium tuberculosis. However, direct identification of latent …

Background Although currently available IGRA have been reported to be promising markers
for TB infection, they cannot distinguish active tuberculosis (TB) from latent infection (LTBI) …

Currently there are no sufficiently validated biomarkers to aid the evaluation of new
tuberculosis vaccine candidates, the improvement of tuberculosis diagnostics or the …

Background Timely and accurate identification of people with latent tuberculosis infection
(LTBI) is important for controlling Mycobacterium tuberculosis (TB). There is no gold …

Latent tuberculosis infection (LTBI) is a subclinical mycobacterial infection defined on the
basis of cellular immune response to mycobacterial antigens. The tuberculin skin test (TST) …