Discovery of the leptin receptor and its downstream peptidergic pathways has reconfirmed
the crucial role of the hypothalamus in the regulation of food intake and energy balance …

Food intake and energy expenditure are controlled by complex, redundant, and distributed
neural systems that reflect the fundamental biological importance of adequate nutrient …

Growing evidence suggests that food intake, energy expenditure and endogenous glucose
production are regulated by hypothalamic areas that respond to a variety of peripheral …

The hormones insulin and leptin have been demonstrated to act in the central nervous
system (CNS) as regulators of energy homeostasis at medial hypothalamic sites. In a …

Body weight is tightly controlled in a species-specific range from insects to vertebrates and
organisms have developed a complex regulatory network in order to avoid either excessive …

The hormones insulin and leptin have been proposed to act in the central nervous system
(CNS) as adiposity signals as part of a theoretical negative feedback loop that senses the …

Although it has been known for more than a century that the brain controls overall energy
balance and adiposity by regulating feeding behavior and energy expenditure, the roles for …

Powerful biological mechanisms evolved to defend adequate nutrient supply and optimal
levels of body weight/adiposity. Low levels of leptin indicating food deprivation and depleted …

The burgeoning obesity epidemic has fueled the drive to describe, mechanistically,
metabolic homeostasis. From the early theories implicating glucose as a principal modulator …

The anorexigenic hormone leptin plays an important role in the control of food intake and
feeding-related behavior, for an important part through its action in the hypothalamus. The …