Synovial inflammation in rheumatoid arthritis is closely related to the formation of ectopic
lymphoid microstructures. In synovial tissue from some patients, one finds seemingly diffuse …

The assembly of inflammatory lesions in rheumatoid arthritis is highly regulated and typically
leads to the formation of lymphoid follicles with germinal center (GC) reactions. We used …

In rheumatoid arthritis (RA), tissue-infiltrating lymphocytes can be arranged in sophisticated
organizations that resemble microstructures usually formed in secondary lymphoid organs …

In rheumatoid synovitis, lymphocytes can be arranged in follicular structures resembling
secondary lymphoid follicles. To understand the organizing principles of this ectopic …

A unique feature in inflammatory tissue of rheumatoid arthritis (RA) is the formation of
ectopic lymphoid aggregates with germinal center (GC)-like structures that can be …

Objective A subset of CD4+ T cells in the synovium of patients with rheumatoid arthritis (RA)
produce CXCL13, a chemokine that is crucial for the formation of germinal centers. This …

Objective Synovial B cells play a critical role in rheumatoid arthritis (RA), being involved in
autoantibody synthesis, T cell activation, and cytokine production. CXCL13 is a B cell …

In about 20% of patients with rheumatoid arthritis, B and T lymphocytes recruited into the
inflamed synovium are organized into complex microstructures, which resemble secondary …

Rheumatoid arthritis results from a T cell-driven inflammation in the synovial membrane that
is frequently associated with the formation of tertiary lymphoid structures. The significance of …

CXCL13 and CCL21 have been functionally implicated in lymphoid tissue organization both
in the upstream phases of lymphoid tissue embryogenesis and in ectopic lymphoid …