Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …

Purinergic signalling appears to play important roles in neurodegeneration, neuroprotection
and neuroregeneration. Initially there is a brief summary of the background of purinergic …

Purinergic signaling modulates dopaminergic neurotransmission in health and disease.
Classically adenosine A 1 and A 2A receptors have been considered key for the fine tune …

By taking advantage of some recently synthesized compounds that are able to block ecto-
ATPase activity, we demonstrated that adenosine triphosphate (ATP) in the hippocampus …

Overactivation of subtype P2X7 receptors can induce excitotoxic neuronal death by calcium
(Ca2+) overload. In this study, we characterize the functional properties of P2X7 receptors …

Abstract Extracellular adenosine 5′-triphosphate (ATP) was proposed to be an activity-
dependent signaling molecule that regulates glia–glia and glia–neuron communications …

Evidence has accumulated in the last three decades to suggest tissue protection and
regeneration by adenosine in multiple different cell types. Adenosine produced in hypoxic or …

The principle functions of neuroinflammation are to limit tissue damage and promote tissue
repair in response to pathogens or injury. While neuroinflammation has utility …

The extracellular concentration of adenosine in the brain increases dramatically during
ischemia. Adenosine A2A receptor is expressed in neurons and glial cells and in …

The emphasis in this article is on the growing interest in the pathophysiology and
therapeutic potential of purinergic signalling. 1–8 However, it begins with a review of the …