RIG-I-like receptors (RLRs), retinoic acid inducible gene I (RIG-I) and melanoma
differentiation-associated protein 5 (MDA5), are pattern recognition receptors through which …

Interferon-stimulated genes (ISGs) create multiple lines of defense against viral infection.
Here, we show that interferon-induced protein 35 (IFI35) inhibits swine (H3N2) influenza …

The retinoic acid-inducible gene I (RIG-I) receptor senses cytoplasmic viral RNA and
activates type I interferons (IFN-I) and downstream antiviral immune responses. How RIG-I …

Retinoic acid‐inducible gene I (RIG‐I) and melanoma differentiation‐associated gene 5
(MDA 5) are cytoplasmic sensors crucial for recognizing different species of viral RNA s …

Influenza B virus causes annual epidemics and, along with influenza A virus, accounts for
substantial disease and economic burden throughout the world. Influenza B virus infects …

A critical role of influenza A virus nonstructural protein 1 (NS1) is to antagonize the host
cellular antiviral response. NS1 accomplishes this role through numerous interactions with …

Retinoic acid-inducible gene-I (RIG-I) is a cytosolic pathogen sensor that is crucial against a
number of viral infections. Many viruses have evolved to inhibit pathogen sensors to …

Abstract Background Influenza A virus (IAV) evolves strategies to counteract the host
antiviral defense for establishing infection. The influenza A virus (IAV) non-structural protein …

During virus infection, RIG-I-like receptors (RLRs) recognize viral RNAs and recruit the
adaptor protein VISA to activate downstream signaling, leading to activation of transcription …

Influenza virus infection causes worldwide seasonal epidemics. Although influenza is
usually a mild disease, a minority of patients experience very severe fulminating disease …