Ochratoxin A–induced genotoxic and epigenetic mechanisms lead to Alzheimer disease: its modulation with strategies

K Niaz, SZA Shah, F Khan, M Bule - Environmental Science and Pollution …, 2020 - Springer
Ochratoxin A (OTA) is a naturally occurring mycotoxin mostly found in food items including
grains and coffee beans. It induces DNA single-strand breaks and has been considered to …

Ochratoxin A: potential epigenetic mechanisms of toxicity and carcinogenicity

B Schilter, M Marin-Kuan, T Delatour… - Food additives and …, 2005 - Taylor & Francis
Assessment of the significance to human health of ochratoxin A (OTA) in food is limited by a
lack of human toxicity data. Therefore, OTA risk evaluation relies mainly on the use of animal …

Ochratoxin A induces apoptosis in neuronal cells

X Zhang, C Boesch-Saadatmandi, Y Lou, S Wolffram… - Genes & nutrition, 2009 - Springer
The mycotoxin ochratoxin A (OTA), which is produced by Aspergillus and Penicillium
subspecies, is a frequently present contaminant of food and feedstuffs. OTA exhibits a wide …

Repeated exposure to Ochratoxin A generates a neuroinflammatory response, characterized by neurodegenerative M1 microglial phenotype

JS Von Tobel, P Antinori, MG Zurich, R Rosset… - Neurotoxicology, 2014 - Elsevier
Neurotoxic effects of the environmentally abundant mycotoxin Ochratoxin A (OTA) were
studied in histotypic 3D rat brain cell cultures, comprising all brain cell types. Cultures were …

Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines

R Ali, RA Mittelstaedt, JG Shaddock, W Ding… - … /Genetic Toxicology and …, 2011 - Elsevier
The fungal toxin, Ochratoxin A (OTA), is a common contaminant in human food and animal
feed. The present study evaluated micronucleus (MN) induction by OTA in comparison with …

Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle …

D Hibi, A Kijima, K Kuroda, Y Suzuki, Y Ishii… - The Journal of …, 2013 - jstage.jst.go.jp
Ochratoxin A (OTA) is a renal carcinogen primarily affecting the S3 segment of proximal
tubules in rodents. In our previous study, we reported that OTA induces reporter gene …

Ochratoxin A: 50 years of research

F Malir, V Ostry, A Pfohl-Leszkowicz, J Malir, J Toman - Toxins, 2016 - mdpi.com
Since ochratoxin A (OTA) was discovered, it has been ubiquitous as a natural contaminant
of moldy food and feed. The multiple toxic effects of OTA are a real threat for human beings …

In vitro gene expression data supporting a DNA non-reactive genotoxic mechanism for ochratoxin A

L Arbillaga, A Azqueta, JHM van Delft… - Toxicology and Applied …, 2007 - Elsevier
Ochratoxin A (OTA) is a mycotoxin often found in cereals and agricultural products. There is
unequivocal evidence of renal carcinogenicity of OTA in male rats, although the mechanism …

Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms

M Marin-Kuan, C Cavin, T Delatour, B Schilter - Toxicon, 2008 - Elsevier
Ochratoxin A (OTA) is a mycotoxin occurring in a wide range of food products. Because of
the limitation of human epidemiological data, the safety significance of OTA in food has to …

Cytotoxic Effects of Ochratoxin A in Neuro-2a Cells: Role of Oxidative Stress Evidenced by N-acetylcysteine

PV Bhat, Pandareesh, F Khanum… - Frontiers in …, 2016 - frontiersin.org
Ochratoxin-A (OTA), is toxic secondary metabolite and is found to be a source of vast range
of toxic effects like hepatotoxicity, nephrotoxicity. However, the information available …