The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability by acting on the
cys-loop cation-conducting ligand-gated nicotinic ACh receptor (nAChR) channels. These …

Background: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that
participate in many physiological functions. Receptors result from the assembly of five …

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are
widely distributed both pre-and post-synaptically in the mammalian brain. By modulating …

Postsynaptic nAChRs in the peripheral nervous system are critical for neuromuscular and
autonomic neurotransmission. Pre-and peri-synaptic nAChRs in the brain modulate …

Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop
ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other …

Although the molecular biology of neuronal nicotinic acetylcholine receptors (nAChRs)
provides evidence for multiple receptor subtypes, few selective pharmacological tools exist …

Until recently, research on (S)-(-)-nicotine (1, hereafter simply nicotine) and nicotinic
acetylcholine receptors (nAChRs) emphasized two principal aspects. The first was the …

Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from
numerous subunit combinations that compose channel-receptor complexes with varied …

Nearly 30 years of experimental evidence supports the argument that ligands of nicotinic
acetylcholine receptors (nAChRs) have potential as therapeutic agents. However, as in the …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion
channels present in the central and peripheral nervous systems, that are permeable to mono …