OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes

AD Barrow, Y Palarasah, M Bugatti… - The Journal of …, 2015 - journals.aai.org
Abstract Surfactant protein D (SP-D) is critical for maintenance of lung homeostasis and
provides a first line of defense to pathogens at mucosal surfaces. Polymorphisms in the SP …

Surfactant protein D regulates airway function and allergic inflammation through modulation of macrophage function

K Takeda, N Miyahara, YH Rha, C Taube… - American journal of …, 2003 - atsjournals.org
The lung collectin surfactant protein D (SP-D) is an important component of the innate
immune response but is also believed to play a role in other regulatory aspects of immune …

[HTML][HTML] Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors

M Yamazoe, C Nishitani, M Takahashi, T Katoh… - Journal of biological …, 2008 - ASBMB
Pulmonary surfactant protein D (SP-D) is a member of the collectin family that plays an
important role in regulating innate immunity of the lung. We examined the mechanisms by …

A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D

R Leth-Larsen, P Garred, H Jensenius… - The Journal of …, 2005 - journals.aai.org
Abstract Surfactant protein D (SP-D) plays important roles in the host defense against
infectious microorganisms and in regulating the innate immune response to a variety of …

Polymorphisms in surfactant protein–D are associated with chronic obstructive pulmonary disease

MG Foreman, X Kong, DL DeMeo, SG Pillai… - American journal of …, 2011 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is characterized by alveolar destruction and
abnormal inflammatory responses to noxious stimuli. Surfactant protein–D (SFTPD) is …

[HTML][HTML] Surfactant protein D in respiratory and non-respiratory diseases

GL Sorensen - Frontiers in medicine, 2018 - frontiersin.org
Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …

Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis

L Zhang, M Ikegami, TR Korfhagen… - … of Physiology-Lung …, 2006 - journals.physiology.org
Surfactant proteins (SP)-A and-D are members of the collectin family of host defense
proteins that share four distinct structural domains: NH2-terminal oligomerization …

[HTML][HTML] Correction of pulmonary abnormalities in Sftpd-/-mice requires the collagenous domain of surfactant protein D

PS Kingma, L Zhang, M Ikegami, K Hartshorn… - Journal of Biological …, 2006 - ASBMB
Surfactant protein D (SP-D) is a member of the collectin family of innate defense proteins.
Members of this family share four distinct structural domains: an N-terminal cross-linking …

[HTML][HTML] Surfactant protein-D and pulmonary host defense

EC Crouch - Respiratory research, 2000 - Springer
Abstract Surfactant protein-D (SP-D) participates in the innate response to inhaled
microorganisms and organic antigens, and contributes to immune and inflammatory …

[HTML][HTML] Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study

MW Sims, RM Tal-Singer, S Kierstein, AI Musani… - Respiratory …, 2008 - Springer
Abstract Background Surfactant protein D (SP-D), an innate immune molecule, plays an
important protective role during airway inflammation. Deficiency of this molecule induces …