With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …

Publisher Summary This chapter highlights resiniferatoxin (RTX) and differences between
RTX and capsaicin actions. Discussion of therapeutic indications of vanilloids in human …

Capsaicin, a well known vanilloid, has shown evidence of an ample variety of biological
effects which make it the target of extensive research ever since its identification. In spite of …

Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent
flavor. Understanding the actions of capsaicin led to the discovery of its receptor, transient …

Capsaicin was postulated to exert its pharmacological actions by interacting at a specific
recognition site (receptor) expressed predominantly by primary afferent neurons. 2. The …

Sensory neurons sensitive to vanilloids (the paradigm of which is capsaicin, the pungent
principle in hot peppers) were visualized by [3H] resiniferatoxin (RTX) autoradiography in …

Capsaicin, the pungent ingredient in hot pepper, activates and subsequently desensitizes a
subset of polymodal nociceptors. Because its initial application to skin produces pain …

Capsaicin, the main pungent ingredient in" hot" chili peppers, elicits burning pain by
activating specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid …

Vanilloid receptors are activated by capsaicin, the pungent ingredient in hot pepper. They
are also specifically and competitively inhibited by capsazepine (CPZ). To determine …

The recently cloned rat vanilloid receptor, VR1, can be activated by capsaicin, acid, and
heat. To determine the molecular mechanisms facilitating channel opening in response to …