[HTML][HTML] shRNA-mediated silencing of the RFC3 gene suppresses hepatocellular carcinoma cell proliferation

Z Yao, K Hu, HE Huang, S Xu… - International …, 2015 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is one of the most common and lethal malignancies
worldwide. Replication factor C (RFC) plays an important role in DNA replication and …

[HTML][HTML] ShRNA-mediated silencing of the RFC3 gene suppress ovarian tumor cells proliferation

H Shen, J Xu, S Zhao, H Shi, S Yao… - International journal of …, 2015 - ncbi.nlm.nih.gov
Ovarian carcinoma is one of the most common and lethal malignancies in the world.
Replication factor C (RFC) plays an important role in DNA replication, DNA damage repair …

The knockdown of endogenous replication factor C4 decreases the growth and enhances the chemosensitivity of hepatocellular carcinoma cells

M Arai, N Kondoh, N Imazeki, A Hada… - Liver …, 2009 - Wiley Online Library
Aims: To identify differentially expressed genes and thereby detect potential molecular
targets for future therapies directed against hepatocellular carcinoma (HCC). Methods: To …

[HTML][HTML] Up-regulated RFC2 predicts unfavorable progression in hepatocellular carcinoma

Z Ji, J Li, J Wang - Hereditas, 2021 - Springer
Abstract Background Replication factor C (RFC) is closely related to tumor progression and
metastasis. However, the functional significance of RFC2 in hepatocellular carcinoma …

[HTML][HTML] Knockdown of RRS1 by lentiviral-mediated RNAi promotes apoptosis and suppresses proliferation of human hepatocellular carcinoma cells

J Wang, Z Li, C Zuo, Q Xie, H Li, J Jia… - Oncology …, 2017 - spandidos-publications.com
In recent years it was found that the synthesis and biological activity of ribosomes are closely
associated with tumor cell growth, tumorigenesis, and malignant transformation. However …

RFC2, a direct target of miR‐744, modulates the cell cycle and promotes the proliferation of CRC cells

T Hu, H Shen, J Li, P Yang, Q Gu… - Journal of Cellular …, 2020 - Wiley Online Library
Colorectal cancer (CRC) is a common digestive tract malignancy, which is characterized by
high mortality, morbidity, and poor prognosis. Replication factor C subunit 2 (RFC2), one …

Overexpression of RFC3 is correlated with ovarian tumor development and poor prognosis

H Shen, M Cai, S Zhao, H Wang, M Li, S Yao, N Jiang - Tumor Biology, 2014 - Springer
Abstract Replication factor C3 (RFC3) is an oncogene that can potentially predict prognosis
in a variety of human cancers. RFC3 expression in ovarian carcinoma has not yet been …

[HTML][HTML] Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer

J Xiang, L Fang, Y Luo, Z Yang, Y Liao, J Cui… - Journal of translational …, 2014 - Springer
Background Human replication factor C4 (RFC4) is involved in DNA replication as a clamp
loader and is aberrantly regulated across a range of cancers. The current study aimed to …

[HTML][HTML] RRP8, associated with immune infiltration, is a prospective therapeutic target in hepatocellular carcinoma

K You, X Du, Y Zhao, F Wen, Z Lu, H Fan - Journal of Cancer Research …, 2024 - Springer
Background Ribosomal RNA Processing 8 (RRP8) is a nucleolar Rossman fold-like
methyltransferase that exhibits increased expression in many malignant tumours. However …

[HTML][HTML] Multifaceted regulation and functions of replication factor C family in human cancers

Y Li, S Gan, L Ren, L Yuan, J Liu, W Wang… - American Journal of …, 2018 - ncbi.nlm.nih.gov
Replication factor C (RFC) family is a complex comprised of the RFC1, RFC2, RFC3, RFC4,
and RFC5 subunits, which acts as a primer recognition factor for DNA polymerase. It is …