Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs

D Charvin, R Medori, RA Hauser… - Nature Reviews Drug …, 2018 - nature.com
Existing therapeutic strategies for managing Parkinson disease (PD), which focus on
addressing the loss of dopamine and dopaminergic function linked with degeneration of …

[HTML][HTML] Recent developments in the treatment of Parkinson's Disease

TB Stoker, RA Barker - F1000Research, 2020 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a common neurodegenerative disease typified by a movement
disorder consisting of bradykinesia, rest tremor, rigidity, and postural instability. Treatment …

Novel targeted therapies for Parkinson's disease

T Ntetsika, PE Papathoma, I Markaki - Molecular Medicine, 2021 - Springer
Parkinson's disease (PD) is the second more common neurodegenerative disease with
increasing incidence worldwide associated to the population ageing. Despite increasing …

Emerging therapeutic strategies for Parkinson's disease and future prospects: A 2021 update

NA Gouda, A Elkamhawy, J Cho - Biomedicines, 2022 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder pathologically distinguished by
degeneration of dopaminergic neurons in the substantia nigra pars compacta. Muscle …

Recent advances in dopaminergic strategies for the treatment of Parkinson's disease

Q Mao, W Qin, A Zhang, N Ye - Acta Pharmacologica Sinica, 2020 - nature.com
Abstracts Parkinson's disease (PD) is the second most common progressive
neurodegenerative disease worldwide. However, there is no available therapy reversing the …

Current approaches to the treatment of Parkinson's Disease

JM Ellis, MJ Fell - Bioorganic & medicinal chemistry letters, 2017 - Elsevier
Parkinson's Disease (PD) is the second most common neurodegenerative disorder. Clinical
approaches to manage PD include symptomatic therapies, serving to compensate for the …

[HTML][HTML] Pathogenesis-targeted, disease-modifying therapies in Parkinson disease

A AlDakheel, LV Kalia, AE Lang - Neurotherapeutics, 2014 - Elsevier
Parkinson disease is an inexorably progressive neurodegenerative disorder. Multiple
attempts have been made to establish therapies for Parkinson disease which provide …

Strategies for the treatment of Parkinson's disease: beyond dopamine

A Iarkov, GE Barreto, JA Grizzell… - Frontiers in aging …, 2020 - frontiersin.org
Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …

Management of Parkinson׳ s disease: Current and future pharmacotherapy

AK Kakkar, N Dahiya - European journal of pharmacology, 2015 - Elsevier
Parkinson׳ s disease (PD) is chronic progressive neurodegenerative disorder characterized
by profound loss of dopaminergic neurons in the nigrostriatal pathway. It is recognized by …

Advances in non-dopaminergic treatments for Parkinson's disease

S Stayte, B Vissel - Frontiers in neuroscience, 2014 - frontiersin.org
Since the 1960's treatments for Parkinson's disease (PD) have traditionally been directed to
restore or replace dopamine, with L-Dopa being the gold standard. However, chronic L …