Blood eosinophilia and tissue eosinophilia are characteristic features of allergic
inflammation and asthma, conditions associated with prominent production of TH2 cytokines …

Asthma is characterized by a 50-to 100-fold increase in the number of eosinophils relative to
neutrophils in the bronchial mucosa. This increase is not the result of a single molecular …

Improved understanding of the contribution of eosinophils to various chronic inflammatory
conditions, most notably allergic asthma, has encouraged development of monoclonal …

Eosinophil-associated disease is a term used to encompass a range of disorders from
hypereosinophilic syndrome to asthma. Despite the longstanding belief that eosinophils can …

Increasing evidence supports a critical role for the eosinophil in disease. Here, the
mechanisms underlying eosinophil-associated inflammation are reviewed including …

Eosinophils play roles in the pathogenesis of various diseases. In order to accumulate within
sites of inflammation, eosinophils must adhere to, and migrate across the microvasculature …

Eosinophil maturation in bone marrow. After allergen-induced latephase reaction, CD34+
cells express IL-5 receptor α-chain. IL-5 drives the CD34+ and IL-5 receptor α-chain+ cells to …

Eosinophils can regulate local immune and inflammatory responses, and their accumulation
in the blood and tissue is associated with several inflammatory and infectious diseases …

As with other types of leukocytes, mechanisms that function to enable the recruitment of
eosinophils into specific sites of immune reactions involve a complex and cumulative …

Compelling evidence has demonstrated that the eosinophils bring negative biological
outcomes in several diseases, including eosinophilic asthma and hypereosinophilic …