Originally rising to notoriety for their role in the regulation of aging, sirtuins are a family of
NAD+-dependent enzymes that have been connected to a steadily growing set of biological …

Aging is accompanied by a decline in the healthy function of multiple organ systems, leading
to increased incidence and mortality from diseases such as type II diabetes mellitus …

The mammalian sirtuins have emerged as critical regulators of cellular stress resistance,
energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age …

Sirtuins have been the focus of intense scrutiny since the discovery of Sir2 as a yeast
longevity factor. Functioning as either deacetylases or ADP ribosylases, Sirtuins are …

Sirtuins are highly conserved nicotinamide adenine dinucleotide (NAD)-dependent
enzymes that regulate a wide range of biological processes, including aging, in several …

The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be
invoked by cells to aid in the defense against a vast array of stressors. The pathologies …

The controversy around sirtuins and their functions in aging has drawn in the past few years
as much attention, if not more, from the scientific community and the public as they did when …

Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human
and SIR2 was originally shown to extend lifespan in budding yeast (Imai et al., 2000; …

Ever since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent
deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as …

Brain aging is characterized by progressive loss of neurophysiological functions that is often
accompanied by age-associated neurodegeneration. Calorie restriction has been linked to …