Rat and sheep cardiac myocytes become binucleate as they complete the 'terminal
differentiation'process soon after birth and are not able to divide thereafter. Angiotensin II …

Angiotensin II (Ang II) stimulates cardiovascular growth and remodeling via AT1receptors.
Recent experiments have shown that Ang II may also exert antiproliferative effects via …

Primary cultures of neonatal cardiac myocytes were used to determine the identity of second
messengers that are involved in angiotensin II (ANG II) receptor-mediated effects on cardiac …

Abstract Angiotensin II (Ang II) is a growth factor that stimulates protein synthesis and
induces cellular hypertrophy in cardiac myocytes. To gain insight into the role of Ang II in …

Objective: We sought to determine whether angiotensin II (Ang II) promotes hypertrophy of
cardiac myocytes directly or via paracrine mechanisms mediated by cardiac fibroblasts …

Cultured neonatal rat cardiac fibroblasts (NF) and myocytes (NM) were used to examine the
distribution of angiotensin II (ANG II) receptors and the potential role of NF in mediating the …

Many lines of evidence have suggested that angiotensin II (Ang II) plays an important role in
cardiac hypertrophy. Ang II not only increases protein synthesis but also induces the …

Angiotensin II (AII) and the endothelins (ET) are known to be potent trophic stimuli in various
cells including cardiomyocytes. In order to characterize further these effects we studied, in …

Increasing evidence suggests that angiotensin II (Ang II) may act as a growth factor for the
heart. However, direct effects of Ang II on mammalian cardiac cells (myocytes and …

In response to humoral and mechanical stimuli, the myocardium adapts to increased work
load through hypertrophy of individual muscle cells. Myocardial hypertrophy is characterized …