Angiotensin II stimulates hyperplasia but not hypertrophy in immature ovine cardiomyocytes
NC Sundgren, GD Giraud, PJS Stork… - The Journal of …, 2003 - Wiley Online Library
Rat and sheep cardiac myocytes become binucleate as they complete the 'terminal
differentiation'process soon after birth and are not able to divide thereafter. Angiotensin II …
differentiation'process soon after birth and are not able to divide thereafter. Angiotensin II …
Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts
CAM Van Kesteren, HAA Van Heugten… - Journal of molecular and …, 1997 - Elsevier
Angiotensin II (Ang II) stimulates cardiovascular growth and remodeling via AT1receptors.
Recent experiments have shown that Ang II may also exert antiproliferative effects via …
Recent experiments have shown that Ang II may also exert antiproliferative effects via …
Hypertrophic growth of cultured neonatal rat heart cells mediated by type 1 angiotensin II receptor
S Miyata, T Haneda - American Journal of Physiology …, 1994 - journals.physiology.org
Primary cultures of neonatal cardiac myocytes were used to determine the identity of second
messengers that are involved in angiotensin II (ANG II) receptor-mediated effects on cardiac …
messengers that are involved in angiotensin II (ANG II) receptor-mediated effects on cardiac …
Upregulation of Cardiac Angiotensin II AT1 Receptors in Congenital Cardiomyopathic Hamsters
C Lambert, Y Massillon, S Meloche - Circulation research, 1995 - Am Heart Assoc
Abstract Angiotensin II (Ang II) is a growth factor that stimulates protein synthesis and
induces cellular hypertrophy in cardiac myocytes. To gain insight into the role of Ang II in …
induces cellular hypertrophy in cardiac myocytes. To gain insight into the role of Ang II in …
Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-β1 and endothelin-1 from fibroblasts
MO Gray, CS Long, JE Kalinyak, HT Li… - Cardiovascular …, 1998 - academic.oup.com
Objective: We sought to determine whether angiotensin II (Ang II) promotes hypertrophy of
cardiac myocytes directly or via paracrine mechanisms mediated by cardiac fibroblasts …
cardiac myocytes directly or via paracrine mechanisms mediated by cardiac fibroblasts …
Trophic effects of angiotensin II on neonatal rat cardiac myocytes are mediated by cardiac fibroblasts
NN Kim, FJ Villarreal, MP Printz… - American Journal of …, 1995 - journals.physiology.org
Cultured neonatal rat cardiac fibroblasts (NF) and myocytes (NM) were used to examine the
distribution of angiotensin II (ANG II) receptors and the potential role of NF in mediating the …
distribution of angiotensin II (ANG II) receptors and the potential role of NF in mediating the …
Angiotensin II Stimulates c-Jun NH2-Terminal Kinase in Cultured Cardiac Myocytes of Neonatal Rats
S Kudoh, I Komuro, T Mizuno, T Yamazaki… - Circulation …, 1997 - Am Heart Assoc
Many lines of evidence have suggested that angiotensin II (Ang II) plays an important role in
cardiac hypertrophy. Ang II not only increases protein synthesis but also induces the …
cardiac hypertrophy. Ang II not only increases protein synthesis but also induces the …
Trophic effect of angiotensin II in neonatal rat cardiomyocytes: role of endothelin‐1 and non‐myocyte cells
K Pönicke, I Heinroth‐Hoffmann… - British journal of …, 1997 - Wiley Online Library
Angiotensin II (AII) and the endothelins (ET) are known to be potent trophic stimuli in various
cells including cardiomyocytes. In order to characterize further these effects we studied, in …
cells including cardiomyocytes. In order to characterize further these effects we studied, in …
Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.
J Sadoshima, S Izumo - Circulation research, 1993 - Am Heart Assoc
Increasing evidence suggests that angiotensin II (Ang II) may act as a growth factor for the
heart. However, direct effects of Ang II on mammalian cardiac cells (myocytes and …
heart. However, direct effects of Ang II on mammalian cardiac cells (myocytes and …
Renin-angiotensin system, hypertrophy and gene expression in cardiac myocytes
P Lijnen, V Petrov - Journal of molecular and cellular cardiology, 1999 - Elsevier
In response to humoral and mechanical stimuli, the myocardium adapts to increased work
load through hypertrophy of individual muscle cells. Myocardial hypertrophy is characterized …
load through hypertrophy of individual muscle cells. Myocardial hypertrophy is characterized …