Ovarian cancer, a highly lethal malignancy among reproductive organ cancers, poses a
significant challenge with its high mortality rate, particularly in advanced-stage cases …

Cisplatin (CDDP) and its derivatives are first line anti-cancer drugs for ovarian cancer
(OVCA). However, chemoresistance due to high incidence of p53 mutations leads to poor …

Aspidin BB, an effective phloroglucinol derivative from Dryopteris fragrans (L.) Schott, has
been previously reported to exert high biological activities. In this study, we analyzed the …

Aims Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers.
Currently, the first-line OC treatment consists of cytoreductive surgery and platinum-based …

Macranthoside B (MB), a saponin compound in Lonicera macranthoides, can block cell
proliferation and induce cell death in several types of cancer cells; however, the precise …

Introduction: Alkaloids derived from M. cordata (Papaveraceae family), have been found to
display antineoplastic activity in several types of cancer. However, the antitumor effects and …

The exploration of drugs derived from natural sources holds significant promise in
addressing current limitations in ovarian cancer (OC) treatments. While previous studies …

Coumarin derivative RKS262 belongs to a new class of potential anti-tumor agents. RKS262
was identified by structural optimization of Nifurtimox which is currently undergoing phase II …

Ovarian cancer (OC) is the most lethal of all gynecologic malignancies with poor survival
rates. Although surgical treatment and chemotherapy had advanced to improve survival …

Ovarian cancers remain one of the most common causes of gynecologic cancer-related
death in women worldwide. The standard treatment comprises platinum-based …