Phloretin induces G2/M arrest and apoptosis by suppressing the β-catenin signaling pathway in colorectal carcinoma cells

S Kapoor, YS Padwad - Apoptosis, 2023 - Springer
Colorectal carcinoma (CRC) is the third most prevalent cancer, causing a significant
mortality worldwide. Present available therapies are surgery, chemotherapy including …

[PDF][PDF] Phloretin flavonoid exhibits selective antiproliferative activity in doxorubicin-resistant gastric cancer cells by inducing autophagy, inhibiting cell migration and …

Q You, J Xu, Z Zhu, Z Hu, Q Cai - J. BUON, 2020 - jbuon.com
Purpose: Studies have shown that Phloretin exerts anticancer effects on several types of
cancer cells. Nonetheless, the anticancer effects of Phloretin have not been fully explored …

Phloretin induces apoptosis of non-small cell lung carcinoma A549 cells via JNK1/2 and p38 MAPK pathways

J Min, X Li, K Huang, H Tang, X Ding… - Oncology …, 2015 - spandidos-publications.com
Phloretin (Ph) existing in apples, pears and various vegetables is known to have antitumor
activities in several cancer cell lines. However, little is known about its effect on human lung …

[HTML][HTML] Anticancer activity of phloretin against human gastric cancer cell lines involves apoptosis, cell cycle arrest, and inhibition of cell invasion and JNK signalling …

M Xu, W Gu, Z Shen, F Wang - Medical Science Monitor …, 2018 - ncbi.nlm.nih.gov
Anticancer Activity of Phloretin Against Human Gastric Cancer Cell Lines Involves Apoptosis,
Cell Cycle Arrest, and Inhibition of Cell Invasion and JNK Signalling Pathway - PMC Back to …

[PDF][PDF] Anticancer activity of Phloretin against the human oral cancer cells is due to G0/G1 cell cycle arrest and ROS mediated cell death

G Yang, X Yin, D Ma, Z Su - J. BUON, 2020 - jbuon.com
Purpose: Phloretin is one of the important polyphenolics abundantly present across the plant
kingdom. Studies have reported the anticancer effects of Phloretin against different human …

A natural flavonoid lawsonaringenin induces cell cycle arrest and apoptosis in HT-29 colorectal cancer cells by targeting multiple signalling pathways

A Anwar, N Uddin, BS Siddiqui, RA Siddiqui… - Molecular biology …, 2018 - Springer
Colorectal cancer is the third most common malignancy in the world having a high mortality
rate. Flavonoids possess many biological activities including anti-cancer activity …

Phloretin exhibits an anticancer effect and enhances the anticancer ability of cisplatin on non-small cell lung cancer cell lines by regulating expression of apoptotic …

L Ma, R Wang, Y Nan, W Li… - … Journal of Oncology, 2016 - spandidos-publications.com
Non-small cell lung cancer (NSCLC) accounts for 80-85% of all lung cancer cases and the
prognosis of NSCLC patients is unsatisfactory since 5-year survival rate of NSCLC is still as …

Quercetin preferentially induces apoptosis in KRAS‐mutant colorectal cancer cells via JNK signaling pathways

Y Yang, T Wang, D Chen, Q Ma, Y Zheng… - Cell biology …, 2019 - Wiley Online Library
Colorectal cancer (CRC) is the third most common type of cancer, and its incidence and
mortality are markedly increasing worldwide. Oncogenic mutations of KRAS occur in up to …

Phloretin induces cell cycle arrest and apoptosis of human glioblastoma cells through the generation of reactive oxygen species

Y Liu, C Fan, L Pu, C Wei, H Jin, Y Teng, M Zhao… - Journal of neuro …, 2016 - Springer
Phloretin, a flavonoid present in various plants, has been reported to exert anticarcinogenic
effects. However, the mechanism of its chemo-preventive effect on human glioblastoma cells …

Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D1 and Survivin Expression through Wnt/β-Catenin Signaling Pathway

BE Shan, MX Wang, R Li - Cancer investigation, 2009 - Taylor & Francis
Aim: The Wnt signaling pathway plays a pivotal role in cellular developmental processes
and human carcinogenesis. The aim of this study was to investigate the effects of quercetin …