Improving effector activity of antigen-specific T cells is a major goal in cancer
immunotherapy. Despite the identification of several effector T cell (T EFF)-driving …

Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based
functional studies in T cells could prioritize novel targets for drug development and improve …

T cell exhaustion limits antitumor immunity, but the molecular determinants of this process
remain poorly understood. Using a chronic stimulation assay, we performed genome-wide …

T cell receptor (TCR) signal strength is a key determinant of T cell responses. We developed
a cancer mouse model in which tumor-specific CD8 T cells (TST cells) encounter tumor …

Tcf1 and Lef1 have versatile functions in regulating T cell development and differentiation,
but intrinsic requirements for these factors in regulatory T (T reg) cells remain to be …

Clinical response to adoptive T cell therapies is associated with the transcriptional and
epigenetic state of the cell product. Thus, discovery of regulators of T cell gene networks and …

As early T cell precursors transition from multipotentiality to T lineage commitment, they
change expression of multiple transcription factors. It is unclear whether individual …

Summary T helper type 2 (Th2) cells are important regulators of mammalian adaptive
immunity and have relevance for infection, autoimmunity, and tumor immunology. Using a …

Identifying molecular mechanisms of exhausted CD8 T cells (Tex) is a key goal of improving
immunotherapy of cancer and other diseases. However, high-throughput interrogation of in …

Abstract Exhausted CD8+ T (Tex) cells are dysfunctional due to persistent antigen exposure
in chronic viral infection and tumor contexts. A stem cell-like Tex (Tex-stem) subset can self …