Our understanding of the multiorgan pathology of cystic fibrosis (CF) has improved
impressively during the last decades, but we still lack a full comprehension of the disease …

Basic and clinical cystic fibrosis research will benefit greatly from the comparative
pathophysiology of cystic fibrosis mice, pigs, and ferrets. Both similarities and differences …

Cystic Fibrosis (CF) is a common autosomal recessive disease that affects multiple organs.
The lack of an animal model with manifestations like those typically found in humans has …

Animal models of cystic fibrosis (CF) are powerful tools that enable the study of the
mechanisms and complexities of human disease. Murine models have several intrinsic …

Animal models of human diseases are critical for dissecting mechanisms of pathophysiology
and developing therapies. In the context of cystic fibrosis (CF), mouse models have been the …

Multiple organ systems, including the gastrointestinal tract, pancreas, and hepatobiliary
systems, are affected by cystic fibrosis (CF). Many of these changes begin early in life and …

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) gene. The resultant characteristic ion transport defect results in decreased …

The lack of an appropriate animal model with multiorgan pathology characteristic of the
human form of cystic fibrosis has hampered our understanding of the pathobiology of the …

The development of mouse models for cystic fibrosis has provided the opportunity to dissect
disease pathogenesis, correlate genotype and phenotype, study disease-modifying genes …

Over the past 30 years, a range of cystic fibrosis (CF) animal models have been generated
for research purposes. Different species, including mice, rats, ferrets, rabbits, pigs, sheep …