Targeting of porous hybrid silica nanoparticles to cancer cells

JM Rosenholm, A Meinander, E Peuhu, R Niemi… - ACS …, 2009 - ACS Publications
Mesoporous silica nanoparticles functionalized by surface hyperbranching polymerization of
poly (ethylene imine), PEI, were further modified by introducing both fluorescent and …

PEG-templated mesoporous silica nanoparticles exclusively target cancer cells

C Morelli, P Maris, D Sisci, E Perrotta, E Brunelli… - Nanoscale, 2011 - pubs.rsc.org
Mesoporous silica nanoparticles (MSNs) have been proposed as DNA and drug delivery
carriers, as well as efficient tools for fluorescent cell tracking. The major limitation is that …

Multifunctional mesoporous silica nanoparticles for cancer‐targeted and controlled drug delivery

Q Zhang, F Liu, KT Nguyen, X Ma… - Advanced Functional …, 2012 - Wiley Online Library
Multifunctional mesoporous silica nanoparticles are developed in order to deliver anticancer
drugs to specific cancer cells in a targeted and controlled manner. The nanoparticle surface …

Tuning the cellular uptake and cytotoxicity properties of oligonucleotide intercalator-functionalized mesoporous silica nanoparticles with human cervical cancer cells …

JL Vivero-Escoto, II Slowing, VSY Lin - Biomaterials, 2010 - Elsevier
A series of organically functionalized, MCM-41 type mesoporous silica nanoparticle
materials (PAP-LP-MSN and AP-PAP-MSN) with different pore sizes (5.7 nm and 2.5 nm …

Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs

T Xia, M Kovochich, M Liong, H Meng, S Kabehie… - ACS …, 2009 - ACS Publications
Surface-functionalized mesoporous silica nanoparticles (MSNP) can be used as an efficient
and safe carrier for bioactive molecules. In order to make the MSNP a more efficient delivery …

Integrated hollow mesoporous silica nanoparticles for target drug/siRNA co‐delivery

X Ma, Y Zhao, KW Ng, Y Zhao - Chemistry–A European …, 2013 - Wiley Online Library
A hollow mesoporous silica nanoparticle (HMSNP) based drug/siRNA co‐delivery system
was designed and fabricated, aiming at overcoming multidrug resistance (MDR) in cancer …

Folic acid-functionalized mesoporous silica nanospheres hybridized with AIE luminogens for targeted cancer cell imaging

Z Wang, B Xu, L Zhang, J Zhang, T Ma, J Zhang, X Fu… - Nanoscale, 2013 - pubs.rsc.org
Fluorescent nanoparticles (FNPs) have been found to be useful as visualization tools for
biological sensing, probing, imaging, and monitoring. Applied to targeted cancer cell …

Silica-based nanoparticles for biomedical applications: from nanocarriers to biomodulators

Y Yang, M Zhang, H Song, C Yu - Accounts of chemical research, 2020 - ACS Publications
Conspectus Silica-based nanoparticles (SNPs) are a classic type of material employed in
biomedical applications because of their excellent biocompatibility and tailorable …

Poly-l-lysine Functionalized Large Pore Cubic Mesostructured Silica Nanoparticles as Biocompatible Carriers for Gene Delivery

SB Hartono, W Gu, F Kleitz, J Liu, L He… - Acs Nano, 2012 - ACS Publications
Large pore mesoporous silica nanoparticles (LP-MSNs) functionalized with poly-l-lysine
(PLL) were designed as a new carrier material for gene delivery applications. The …

Cancer-cell targeting and cell-specific delivery by mesoporous silica nanoparticles

J Rosenholm, C Sahlgren, M Lindén - Journal of Materials Chemistry, 2010 - pubs.rsc.org
Mesoporous silica nanoparticles (MSNs) have emerged as promising drug carriers. Here we
highlight some recent developments related to cell-specific targeting and delivery using …