Background Diabetes always involves variable degrees of β-cell demise and malfunction
leading to insufficient insulin secretion. Besides clinical investigations, many research …

Insulin secretion by β-cells is largely controlled by circulating nutrients, hormones, and
neurotransmitters. However, recent years have witnessed the multiplication of studies …

In vitro studies of human pancreatic islets are critical for understanding normal insulin
secretion and its perturbations in diabetic β‐cells, but the influence of islet preparation …

The biphasic pattern of glucose-induced insulin secretion is altered in type 2 diabetes.
Impairment of the first phase is an early sign of β-cell dysfunction, but the underlying …

The control of hormone secretion is central to body homeostasis, and its dysfunction is
important in many diseases. The key cellular steps that lead to hormone secretion have …

Although initially described two decades ago, biphasic insulin secretion has gradually been
understood to reflect (β-cell rate sensitivity, be important in minimizing overinsulinization in …

Background An increased access of research laboratories to isolated human islets has
improved our understanding of the biology of the endocrine pancreas and hence the …

Plasma insulin in healthy subjects shows regular oscillations, which are important for the
hypoglycemic action of the hormone. In individuals with type 2 diabetes, these regular …

We investigated the effect of 24 h of exposure to various glucose concentrations on insulin
secretion by isolated rat pancreatic islets and purified rat β-cells. Compared with islets …

The understanding of the etiology of type 1 diabetes (T1D) remains limited. One objective of
the Diabetes Virus Detection (DiViD) study was to collect pancreatic tissue from living …