TYK2 is a key mediator of IL12, IL23, and type I interferon signaling, and these cytokines
have been implicated in the pathogenesis of multiple inflammatory and autoimmune …

A member of the Janus kinase (JAK) family, Tyrosine Kinase 2 (TYK2), is crucial in
mediating various cytokine-signaling pathways such as interleukin-23 (IL23), interleukin-12 …

As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an
important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL …

Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family that regulates signal
transduction downstream of receptors for the IL-23/IL-12 pathways and type I interferon …

Herein we report our lead optimization effort to identify potent, selective, and orally
bioavailable TYK2 inhibitors, starting with lead molecule 3. We used structure-based design …

As a member of the Janus (JAK) family of non-receptor tyrosine kinases, TYK2 mediates the
signaling of pro-inflammatory cytokines including IL-12, IL-23 and type 1 interferon (IFN) …

The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate
the intracellular signaling of cytokines in a wide spectrum of cellular processes. They …

A therapeutic rationale is proposed for the treatment of inflammatory diseases, such as
psoriasis and inflammatory bowel diseases (IBD), by selective targeting of TYK2. Hit triage …

ABSTRACT Introduction: Tyrosine kinase 2 (Tyk2) is a non-receptor tyrosine-protein kinase,
an enzyme that in humans is encoded by the TYK2 gene. Tyk2, together with three other …

Small molecule JAK inhibitors have emerged as a major therapeutic advancement in
treating autoimmune diseases. The discovery of isoform selective JAK inhibitors that …