ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling
The deaminase ADAR1 edits adenosines in nuclear transcripts of nervous tissue and is
required in the fetal liver of the developing mouse embryo. Here we show by inducible gene …
required in the fetal liver of the developing mouse embryo. Here we show by inducible gene …
ADAR1 is required for hematopoietic progenitor cell survival via RNA editing
R XuFeng, MJ Boyer, H Shen, Y Li… - Proceedings of the …, 2009 - National Acad Sciences
Adenosine Deaminase Acting on RNA 1 (ADAR1) is an RNA-editing enzyme that converts
adenosine to inosine, following RNA transcription. ADAR1's essential role in embryonic …
adenosine to inosine, following RNA transcription. ADAR1's essential role in embryonic …
ADAR RNA editing in human disease; more to it than meets the I
We review the structures and functions of ADARs and their involvements in human diseases.
ADAR1 is widely expressed, particularly in the myeloid component of the blood system, and …
ADAR1 is widely expressed, particularly in the myeloid component of the blood system, and …
Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1
JC Hartner, C Schmittwolf, A Kispert, AM Muller… - Journal of Biological …, 2004 - ASBMB
ADAR1 (adenosine deaminase acting on RNA-1) is widely expressed in mammals, but its
biological role is unknown. We show here by gene targeting that ADAR1 selectively edits in …
biological role is unknown. We show here by gene targeting that ADAR1 selectively edits in …
Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
Systematic exploration of cancer cell vulnerabilities can inform the development of novel
cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we …
cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we …
ADAR1 editing and its role in cancer
LD Xu, M Öhman - Genes, 2018 - mdpi.com
It is well established that somatic mutations and escape of immune disruption are two
essential factors in cancer initiation and progression. With an increasing number of second …
essential factors in cancer initiation and progression. With an increasing number of second …
Expression of interferon-inducible RNA adenosine deaminase ADAR1 during pathogen infection and mouse embryo development involves tissue-selective promoter …
CX George, MV Wagner, CE Samuel - Journal of Biological Chemistry, 2005 - ASBMB
ADAR1 (adenosine deaminase acting on RNA) is widely expressed in adult mammals and
has a critical role during embryogenesis. Two size forms of ADAR1 are known that possess …
has a critical role during embryogenesis. Two size forms of ADAR1 are known that possess …
ADAR1 and its implications in cancer development and treatment
AR Baker, FJ Slack - Trends in Genetics, 2022 - cell.com
The family of adenosine deaminases acting on RNA (ADARs) regulates global gene
expression output by catalyzing adenosine-to-inosine (A-to-I) editing of double-stranded …
expression output by catalyzing adenosine-to-inosine (A-to-I) editing of double-stranded …
The role of RNA editing enzyme ADAR1 in human disease
B Song, Y Shiromoto, M Minakuchi… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Adenosine deaminase acting on RNA (ADAR) catalyzes the posttranscriptional conversion
of adenosine to inosine in double‐stranded RNA (dsRNA), which can lead to the creation of …
of adenosine to inosine in double‐stranded RNA (dsRNA), which can lead to the creation of …
The RNA-editing enzyme ADAR1 controls innate immune responses to RNA
NM Mannion, SM Greenwood, R Young, S Cox… - Cell reports, 2014 - cell.com
The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs.
Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi …
Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi …