Cytokine and growth factor signaling mediates essential roles in the differentiation,
proliferation, survival and function of a number of cell lineages. This is achieved via specific …

Suppressor of cytokine signalling (SOCS) proteins are inhibitors of cytokine signalling
pathways. Studies have shown that SOCS proteins are key physiological regulators of both …

Cytokine signaling represents one of the cornerstones of the immune system, mediating the
complex responses required to facilitate appropriate immune cell development and function …

Cytokines regulate the growth and differentiation of cells by binding to cell-surface receptors
and activating intracellular signal transduction cascades such as the JAK-STAT pathway …

Receptor tyrosine kinases (RTKs) are a family of cell surface receptors that play critical roles
in signal transduction from extracellular stimuli. Many in this family of kinases are …

Regulation of many aspects of cell behaviour occurs through the interaction of cytokines with
specific cell surface receptors, resulting in the activation of cytoplasmic signal transduction …

The suppressor of cytokine signaling (SOCS) family of proteins are key negative regulators
of cytokine and growth factor signaling. They act at the receptor complex to modulate the …

Immune and inflammatory systems are controlled by multiple cytokines, including
interleukins and interferons. Many of these cytokines exert their biological functions through …

Cytokines regulate cellular behavior by interacting with receptors on the plasma membrane
of target cells and activating intracellular signal transduction cascades such as the JAK …

Members of the SOCS (suppressor of cytokine signalling) family of proteins play key roles in
the negative regulation of cytokine signal transduction. A series of elegant biochemical and …