Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Focal adhesions (FAs) are specialized sites of cell attachment to the extracellular matrix
(ECM) where integrin receptors link the ECM to the actin cytoskeleton. Integrins cluster into …

The ability of animal cells to sense, adhere to and remodel their local extracellular matrix
(ECM) is central to control of cell shape, mechanical responsiveness, motility and signalling …

The ability of cells to migrate is a fundamental physiological process involved in embryonic
development, tissue homeostasis, immune surveillance and wound healing. In order for …

Integrin adhesions are a structurally and functionally diverse family of transmembrane, multi-
protein complexes that link the intracellular cytoskeleton to the extracellular matrix (ECM) …

Simple Summary The cytoskeleton is a network of protein fibres within cells that provide
structure and support intracellular transport. Focal adhesions are protein complexes …

The regulation of cell adhesion machinery is central to a wide variety of developmental and
pathological processes and occurs primarily within integrin-associated adhesion complexes …

Cell–cell and cell–extracellular-matrix (cell–ECM) adhesions have much in common,
including shared cytoskeletal linkages, signaling molecules and adaptor proteins that serve …

Integrin-linked focal adhesion complexes provide the main sites of cell adhesion to
extracellular matrix and associate with the actin cytoskeleton to control cell movement …

Engagement of integrin receptors with extracellular ligands gives rise to the formation of
complex multiprotein structures that link the ECM to the cytoplasmic actin cytoskeleton …