CD 95 (also known as Fas) is a member of the tumor necrosis factor receptor (TNFR)
superfamily. Its cognate ligand, CD 95L, is implicated in immune homeostasis and immune …

CD95 (also known as Fas) is the prototype of death receptors; however, evidence suggests
that this receptor mainly implements non-apoptotic signaling pathways such as NF-κB …

CD95 is a death receptor whose stimulation by either the physiologic ligand CD95L or the
agonistic antibodies leads to the formation of a multi-molecular complex termed DISC (death …

Abstract CD95 (Apo1/Fas) has been originally identified as the target of cell death-inducing
antibodies. The recognition of CD95 as an apoptosis-triggering receptor represents one of …

Endothelial cells lining new blood vessels that develop during inflammatory disorders or
cancers act as doors that either allow or block access to the tumor or inflamed organ. Recent …

The CD95/Fas/Apo-1 ligand (CD95L, CD178) induces apoptosis through the death receptor
CD95. CD95L was also described as a co-stimulatory receptor for T-cell activation in mice in …

FasL (CD95L) is a well-known and well-characterized death-inducing ligand. Spontaneous
mutations in FasL and its cognate receptor Fas (CD95) have helped understand the role of …

The CD95 ligand is involved as a death factor in the regulation of activation-induced cell
death, establishment of immune privilege and tumor cell survival. In addition, CD95L may …

Since the ligand for the death factor CD95 (CD95L) was identified almost a decade ago, it
has been established that this molecule (CD95L, FasL, Apo-1L, CD178, TNFSF6, APT1LG1) …

Although the interaction of CD95L (also known as FasL) with its so-called death receptor
CD95 (Fas) induces an apoptotic signal responsible for the elimination of infected and …