Nanodelivery of nucleic acids

BB Mendes, J Conniot, A Avital, D Yao… - Nature reviews …, 2022 - nature.com
There is growing need for a safe, efficient, specific and non-pathogenic means for delivery of
gene therapy materials. Nanomaterials for nucleic acid delivery offer an unprecedented …

Biomedical applications of nanomaterials in the advancement of nucleic acid therapy: Mechanistic challenges, delivery strategies, and therapeutic applications

K Yadav, KK Sahu, SPE Gnanakani, P Sure… - International Journal of …, 2023 - Elsevier
In the past few decades, substantial advancement has been made in nucleic acid (NA)-
based therapies. Promising treatments include mRNA, siRNA, miRNA, and anti-sense DNA …

Cancer‐targeting nanoparticles for combinatorial nucleic acid delivery

HJ Vaughan, JJ Green, SY Tzeng - Advanced Materials, 2020 - Wiley Online Library
Nucleic acids are a promising type of therapeutic for the treatment of a wide range of
conditions, including cancer, but they also pose many delivery challenges. For efficient and …

Recent advances in nanomaterials for gene delivery—a review

MK Riley, W Vermerris - Nanomaterials, 2017 - mdpi.com
With the rapid development of nanotechnology in the recent decade, novel DNA and RNA
delivery systems for gene therapy have become available that can be used instead of viral …

[图书][B] Advances in nanomedicine for the delivery of therapeutic nucleic acids

S Nimesh, R Chandra, N Gupta - 2017 - books.google.com
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several
issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A …

Nanoparticles for vaccine and gene therapy: Overcoming the barriers to nucleic acid delivery

LM Mollé, CH Smyth, D Yuen… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Nucleic acid therapeutics can be used to control virtually every aspect of cell behavior and
therefore have significant potential to treat genetic disorders, infectious diseases, and …

[HTML][HTML] At the intersection of biomaterials and gene therapy: progress in non-viral delivery of nucleic acids

H Uludag, A Ubeda, A Ansari - Frontiers in bioengineering and …, 2019 - frontiersin.org
Biomaterials play a critical role in technologies intended to deliver therapeutic agents in
clinical settings. Recent explosion of our understanding of how cells utilize nucleic acids has …

Exploring the role of polymer structure on intracellular nucleic acid delivery via polymeric nanoparticles

CJ Bishop, KL Kozielski, JJ Green - Journal of Controlled Release, 2015 - Elsevier
Intracellular nucleic acid delivery has the potential to treat many genetically-based diseases,
however, gene delivery safety and efficacy remains a challenging obstacle. One promising …

[PDF][PDF] Nanomaterials for therapeutic RNA delivery

X Han, MJ Mitchell, G Nie - Matter, 2020 - cell.com
Recent years have witnessed tremendous developments and breakthroughs in the field of
RNA-based therapeutics. The distinct mechanisms of exogenous RNAs and analogs …

Smart nanocarriers for the delivery of nucleic acid‐based therapeutics: a comprehensive review

T Ramasamy, S Munusamy, HB Ruttala… - Biotechnology …, 2021 - Wiley Online Library
Nucleic acid‐based therapies are promising therapeutics for the treatment of several
systemic disorders, and they offer an exciting opportunity to address emerging biological …