Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate
biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme …

Increases in cell death by programmed (ie, apoptosis, autophagy) or nonprogrammed
mechanisms (ie, necrosis) occur during tissue injury and may contribute to the etiology of …

Heme oxygenase-1 (HO-1) is an inducible stress protein that catalyzes the oxidative
conversion of heme to carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is …

Heme oxygenase-1 (HO-1), a ubiquitous inducible stress-response protein, serves a major
metabolic function in heme turnover. HO activity cleaves heme to form biliverdin-IXα, carbon …

Heme oxygenase (HO) breaks down heme, the iron-containing, oxygen-carrying constituent
of red blood cells, yielding biliverdin, iron (II) ions, and carbon monoxide (CO). Among the …

Abstract Heme oxygenase-1 (HO-1), an inducible stress protein, confers cytoprotection
against oxidative stress in vitro and in vivo. In addition to its physiological role in heme …

Heme oxygenase (HO)-1 catalyzes the oxidative cleavage of heme to yield equimolar
amounts of biliverdin, iron, and carbon monoxide. HO-1 is a stress response protein, the …

The lungs are a major target for various inflammatory, oxidative, carcinogenic or infectious
stressors, which result in a range of lung diseases. Induction of heme oxygenase-1 (HO-1) …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remain major
causes of morbidity and mortality in critical care medicine despite advances in therapeutic …

Abstract Heme oxygenase-1 (HO-1) is an inducible enzyme that catalyzes oxidative
degradation of heme to form biliverdin, carbon monoxide (CO), and free iron. Biliverdin is …