Publisher Summary This chapter reviews the general features of rickets, classification of the
various causes of the disease, and nutritional rickets. Rickets is a clinical syndrome …

Bone accretion is a two-stage process, with the osteoblasts laying down osteoid, which is
then mineralized. Mineralization of osteoid requires vitamin D to be available in its active …

Rickets is the clinical consequence of impaired mineralization of bone matrix throughout the
growing skeleton in children, whilst osteomalacia is the result of this disturbance after the …

Calcium, present within bone as crystals of hydroxyapatite (Ca10 (PO4) 6 (OH) 2),
comprises about 40% of bone mass. During bone growth in infancy and childhood …

Rickets is a bone disease associated with abnormal serum calcium and phosphate levels.
The clinical presentation is heterogeneous and depends on the age of onset and …

Rickets is a condition that has been recognized for many centuries and is due to defective
mineralization of the growth plate in growing children. This defect compromises the …

Since the introduction of better diets with ample vitamin supplements by more enlightened
mothers, and the virtual disappearance of infantile rickets due to lack of vitamin D, increased …

Rickets is disorder of a growing child arising from disorders that result in impaired apoptosis
of hypertrophic cells and mineralization of the growth plate. Rickets due to nutritional causes …

Hypophosphatemic rickets typically presents in infancy or early childhood with skeletal
deformities and growth plate abnormalities. The most common causes are genetic (such as …

The article focuses on genetic and dietary factors leading to rickets, a bone disease. Vitamin
D insufficiency is a major contributing factor as the disease can be prevented by ensuring an …