Targeting circular RNAs as a therapeutic approach: current strategies and challenges

AT He, J Liu, F Li, BB Yang - Signal transduction and targeted therapy, 2021 - nature.com
Significant progress has been made in circular RNA (circRNA) research in recent years.
Increasing evidence suggests that circRNAs play important roles in many cellular processes …

Circular RNAs as therapeutic agents and targets

LM Holdt, A Kohlmaier, D Teupser - Frontiers in physiology, 2018 - frontiersin.org
It has recently been reported that thousands of covalently linked circular RNAs (circRNAs)
are expressed from human genomes. circRNAs emerge during RNA splicing. circRNAs are …

Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines

X Liu, Y Zhang, S Zhou, L Dain, L Mei, G Zhu - Journal of Controlled …, 2022 - Elsevier
Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5′
or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA …

The design and synthesis of circular RNAs

P Obi, YG Chen - Methods, 2021 - Elsevier
Circular RNAs (circRNAs) are a novel class of RNAs distinguished by their single-stranded,
covalently-closed topology. Although initially perceived as rare byproducts of aberrant …

Circular RNA: an important player with multiple facets to regulate its parental gene expression

T Shao, Y Pan, X Xiong - Molecular Therapy-Nucleic Acids, 2021 - cell.com
Circular RNAs (circRNAs), a novel type of endogenous RNAs with covalently closed-loop
structures, have become a new research hotspot in the RNA world. Their diversity, stability …

Circular RNAs: expression, localization, and therapeutic potentials

Q Yang, F Li, AT He, BB Yang - Molecular therapy, 2021 - cell.com
Circular RNAs (circRNAs) are RNAs with a unique circular structure that is generated from
back-splicing processes. These circular molecules were discovered more than 40 years ago …

Circular RNA and its mechanisms in disease: from the bench to the clinic

B Han, J Chao, H Yao - Pharmacology & therapeutics, 2018 - Elsevier
The emerging recognition of the functional roles of circular RNAs (circRNAs) has given rise
to a new perspective regarding our understanding of cellular physiology and disease …

[HTML][HTML] Advances in circular RNA and its applications

X Zhao, Y Zhong, X Wang, J Shen… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Circular RNA (circRNA) is a novel endogenous non-coding RNA (ncRNA) that, like
microRNA (miRNA), is a rapidly emerging RNA research topic. CircRNA, unlike traditional …

Circular RNAs: emerging regulators of the major signaling pathways involved in cancer progression

M Papatsirou, PI Artemaki, P Karousi, A Scorilas… - Cancers, 2021 - mdpi.com
Simple Summary Circular RNAs (circRNAs) are single-stranded RNA molecules that form a
covalently closed loop structure. They are characterized by distinct features and …

Recent research progress on circular RNAs: Biogenesis, properties, functions, and therapeutic potential

AR Sharma, M Bhattacharya, S Bhakta, A Saha… - … Therapy-Nucleic Acids, 2021 - cell.com
Circular RNAs (circRNAs), an emerging family member of RNAs, have gained importance in
research due to their new functional roles in cellular physiology and disease progression …