The present study was designed to explore the relationship between the cannabinoid and
opioid receptors in animal models of opioid-induced reinforcement. The acute administration …

RECENT reports have provided evidence of a link between the endogenous brain
cannabinoid system and the endogenous central opioid systems. Here we report that the …

Recent evidence indicates that cannabinoid-1 (CB 1) receptors play a role in the mediation
of opiate reward, though the neural mechanisms for this process have not been …

Rationale Recently, we provided evidence for a cannabinoid mechanism in relapse to
cocaine seeking in rats. There is also increasing evidence for functional cross-talk between …

Activation or blockade of cannabinoid CB1 receptors markedly alters many effects of
opioids. In the present study, we investigated whether the cannabinoid antagonist (N …

Cannabinoids produce a variety of pharmacological effects very similar to those elicited by
opioids. Direct and indirect interactions with opioid system have been proposed to explain …

Accumulating evidence suggests that the endogenous cannabinoid system is involved in the
reinforcing effects of heroin. In rats intravenously self-administering heroin, we investigated …

In the present study, we examined the effects of endogenous ligand 2-arachidonoylglycerol
(2-AG) on naloxone-precipitated withdrawal in morphine-dependent mice, in comparison …

Withdrawal from opiates, such as heroin or oral narcotics, is characterized by a host of
aversive physical and emotional symptoms. High rates of relapse and limited treatment …

The opioid and cannabinoid systems co‐operate to regulate physiological processes such
as nociception and reward. The endocannabinoid system may be a component of the brain …