Inhibiting oestrogen signalling in pulmonary arterial hypertension: sex, drugs and research

T Lahm, SM Kawut - European Respiratory Journal, 2017 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a sexually dimorphic disease that affects women
more than men. Several pre-clinical and clinical studies identified 17β-oestradiol (E2), the …

Pulmonary arterial hypertension: basis of sex differences in incidence and treatment response

KM Mair, AKZ Johansen, AF Wright… - British journal of …, 2014 - Wiley Online Library
Pulmonary arterial hypertension (PAH) is a complex disease characterized by elevated
pulmonary arterial pressure, pulmonary vascular remodelling and occlusive pulmonary …

2-Methoxyestradiol in pulmonary arterial hypertension: a new disease modifier

SP Tofovic, EK Jackson - Interventional Pulmonology and …, 2019 - books.google.com
Pulmonary arterial hypertension (PAH), a debilitating and incurable disease, predominantly
develops in women. Estradiol metabolism leads to the production of numerous metabolites …

The influence of sex hormones on pulmonary vascular reactivity: possible vasodilator therapies for the treatment of pulmonary hypertension

AM Smith, RD Jones… - Current vascular …, 2006 - ingentaconnect.com
Pulmonary hypertension is a rare disease of the pulmonary vasculature defined as a mean
pulmonary artery pressure> 25 mmHg at rest or 30 mmHg with exercise. Recent therapies …

Estradiol metabolism: crossroads in pulmonary arterial hypertension

SP Tofovic, EK Jackson - International journal of molecular sciences, 2019 - mdpi.com
Pulmonary arterial hypertension (PAH) is a debilitating and progressive disease that
predominantly develops in women. Over the past 15 years, cumulating evidence has …

Beyond oestrogens: towards a broader evaluation of the hormone profile in pulmonary arterial hypertension

JB Badlam, ED Austin - European Respiratory Journal, 2018 - Eur Respiratory Soc
Beyond oestrogens: towards a broader evaluation of the hormone profile in pulmonary arterial
hypertension | European Respiratory Society Skip to main content Main menu Home Current …

Complexities of oestradiol pharmacology in pulmonary arterial hypertension

P Yuan, L Gao, ZC Jing - European Respiratory Journal, 2013 - Eur Respiratory Soc
We thank SP Tofovic and EK Jackson for their interest in our study [ 1]. It is well known that
pulmonary arterial hypertension (PAH) is a female-predominant disease [ 2–4], and this …

Oestrogen and the sexual dimorphism of pulmonary arterial hypertension: a translational challenge

JK Paulus, KE Roberts - European Respiratory Journal, 2013 - Eur Respiratory Soc
The striking female predominance in idiopathic and familial pulmonary arterial hypertension
(PAH) has been well documented since the publication of the National Institutes of Health …

The estrogen paradox in pulmonary arterial hypertension

S Sakao, N Tanabe, K Tatsumi - American Journal of …, 2010 - journals.physiology.org
Idiopathic pulmonary arterial hypertension (PAH) is a disabling condition characterized by
PA vasoconstriction and remodeling as well as in situ thrombosis and eventual right heart …

Estrogens in men: another layer of complexity of estradiol metabolism in pulmonary hypertension

SP Tofovic, EK Jackson - … Journal of Respiratory and Critical Care …, 2016 - atsjournals.org
The fact that pulmonary arterial hypertension (PAH) is more common in women than in men
(1) suggests that estrogens importantly contribute to the pathophysiology of PAH (2) …