Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its
prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating …

Accumulating evidence indicates that obesity is closely associated with an increased risk of
metabolic diseases such as insulin resistance, type 2 diabetes, dyslipidemia and …

Many approaches have been used in the effective management of type 2 diabetes mellitus.
A recent paradigm shift has focused on the role of adipose tissues in the development and …

Adipose, or fat, tissue (AT) was once considered an inert tissue that primarily existed to store
lipids, and was not historically recognized as an important organ in the regulation and …

The burden of obesity has increased globally over the last few decades and its association
with insulin resistance and related cardio-metabolic problems have adversely affected our …

The dysregulation of the β-cell functional mass, which is a reduction in the number of β-cells
and their ability to secure adequate insulin secretion, represents a key mechanistic factor …

Currently, obesity has become a global health issue and is referred to as an epidemic.
Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin …

Obesity-associated insulin resistance is a complex disorder involving a number of candidate
molecules, pathways and transduction systems possessing potential causal actions …

Obesity is frequently associated with chronic inflammation, metabolic and vascular
alterations which predispose to the development of the Metabolic Syndrome (MetS) …

Metabolic syndrome (MetS) is a common global problem that comprises the cardio-
metabolic cluster and predisposes to both diabetes and cardiovascular diseases. Although …