Considerable evidence implies that an enteroviral infection may accelerate or precipitate
type 1 diabetes (T1D) in some individuals. However, causality is not proven. We present and …

The question if enteroviruses could cause beta-cell damage and type 1 diabetes has
become more and more relevant when recent studies have provided new evidence …

Environmental factors, especially viruses, are involved in the initiation or the acceleration of
type 1 diabetes (T1D) pathogenesis. Epidemiological data strongly suggest that …

Type 1 (insulin-dependent) diabetes is a typical organ-specific autoimmune disease where
insulin-producing beta cells are destroyed by immune mediated mechanisms. The risk of the …

Background Human enteroviruses, which are transmitted via a faecal‐oral route, have long
been associated with type 1 diabetes onset. Increased hygiene in the 20th century may now …

Enteroviruses (EV) have been historically associated to type 1 diabetes. Definitive proof for
their implication in disease development is lacking, but growing evidence suggests that they …

Highlights•Enteroviral infection has been long-associated with type 1 diabetes in
epidemiological studies.•β-Cells express a specific enteroviral receptor isoform, CAR-SIV …

Common enterovirus infections appear to initiate or facilitate the pathogenetic processes
leading to type 1 diabetes, and sometimes also precipitate the clinical disease. It is not …

The pathogenesis of type 1 diabetes is widely believed to involve T cell-mediated
autoimmune processes directed against the insulin-producing beta cells in the pancreas …

Summary OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW
SERIES Metabolic diseases, host responses, cancer, autoinflammatory diseases, allergy …