The purpose of the current study was to investigate the effect of the recently synthesized
mitochondrially-targeted H 2 S donor, AP39 [(10-oxo-10-(4-(3-thioxo-3H-1, 2-dithiol-5yl) …

Synthesis and bioavailability of the endogenous gasomediator hydrogen sulfide (H2S) is
perturbed in many disease states, including those involving mitochondrial dysfunction …

The development of diabetic vascular complications is initiated, at least in part, by
mitochondrial reactive oxygen species (ROS) production in endothelial cells. Hyperglycemia …

Background Hydrogen sulfide (H2S) has been shown to have cytoprotective effects in
models of hypertension, ischemia/reperfusion and Alzheimer's disease. However, little is …

It has been proposed that homocysteine (Hcy)-induces endothelial dysfunction and
atherosclerosis by generation of reactive oxygen species (ROS). A previous report has …

Background and Purpose H2S protects myocardium against ischaemia/reperfusion injury.
This protection may involve the cytosolic reperfusion injury salvage kinase (RISK) pathway …

Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition
of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its …

Therapeutic manipulation of the gasotransmitter hydrogen sulfide (H2S) has recently been
proposed as a novel targeted anticancer approach. Here we show that human lung …

Mitochondria-targeted H 2 S donors are thought to protect against acute ischemia-
reperfusion (IR) injury by releasing H 2 S that decreases oxidative damage. However, the …

Mitochondria and NADPH oxidase activation are concomitantly involved in pathogenesis of
many vascular diseases. However, possible cross-talk between those ROS-generating …