Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection

H Scholz, FJ Boivin, KM Schmidt-Ott… - Nature Reviews …, 2021 - nature.com
Kidney damage varies according to the primary insult. Different aetiologies of acute kidney
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …

Ischemic kidney injury and mechanisms of tissue repair

ME Sabbahy, VS Vaidya - Wiley Interdisciplinary Reviews …, 2011 - Wiley Online Library
Acute kidney injury (AKI) may result from ischemia or by the use of nephrotoxic agents. The
incidence of AKI is variable, depends on comorbidities, and ranges from 5 to 35% in all …

[HTML][HTML] Acute kidney injury: changing lexicography, definitions, and epidemiology

J Himmelfarb, TA Ikizler - Kidney international, 2007 - Elsevier
In recent years, there have been numerous advances in understanding the molecular
determinants of functional kidney injury after ischemic and/or toxic exposure. However …

[HTML][HTML] Acute kidney injury

A Zuk, JV Bonventre - Annual review of medicine, 2016 - annualreviews.org
Acute kidney injury (AKI) is a global public health concern associated with high morbidity,
mortality, and healthcare costs. Other than dialysis, no therapeutic interventions reliably …

[HTML][HTML] Renal ischemia/reperfusion injury; from pathophysiology to treatment

M Malek, M Nematbakhsh - Journal of renal injury prevention, 2015 - ncbi.nlm.nih.gov
Ischemia/reperfusion injury (IRI) is caused by a sudden temporary impairment of the blood
flow to the particular organ. IRI usually is associated with a robust inflammatory and …

[HTML][HTML] Pathophysiology of acute kidney injury

DP Basile, MD Anderson, TA Sutton - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Renal hypoxia in kidney disease: cause or consequence?

CPC Ow, JP Ngo, MM Ullah, LM Hilliard… - Acta …, 2018 - Wiley Online Library
Tissue hypoxia has been proposed as an important factor in the pathophysiology of both
chronic kidney disease (CKD) and acute kidney injury (AKI), initiating and propagating a …

Recent advances in acute kidney injury and its consequences and impact on chronic kidney disease

A Zuk, JV Bonventre - Current opinion in nephrology and …, 2019 - journals.lww.com
Recent advances in acute kidney injury and its consequences... : Current Opinion in
Nephrology and Hypertension Recent advances in acute kidney injury and its …

The pathogenesis of acute kidney injury and the toxic triangle of oxygen, reactive oxygen species and nitric oxide

U Aksu, C Demirci, C Ince - Controversies in Acute Kidney Injury, 2011 - karger.com
Despite the identification of several of the cellular mechanisms thought to underlie the
development of acute kidney injury (AKI), the pathophysiology of AKI is still poorly …

Renal oxygenation and haemodynamics in acute kidney injury and chronic kidney disease

P Singh, SE Ricksten, G Bragadottir… - Clinical and …, 2013 - Wiley Online Library
Acute kidney injury (AKI) is a major burden on health systems and may arise from multiple
initiating insults, including ischaemia‐reperfusion injury, cardiovascular surgery …