CXCR4 is a pleiotropic chemokine receptor which acts through its ligand CXCL12 to
regulate diverse physiological processes. CXCR4/CXCL12 axis plays a pivotal role in …

Background We assessed the mechanism by which multiple myeloma (MM) shapes the
bone marrow (BM) microenvironment and affects MΦ polarization. Methods In vivo xenograft …

Extra-medullary disease (EMD) in multiple myeloma (MM) is associated with poor prognosis
and resistance to chemotherapy. However, molecular alterations that lead to EMD have not …

Multiple myeloma (MM) cells specifically attract peripheral-blood monocytes, while
interaction of MM with bone marrow stromal cells (BMSCs) significantly increased monocyte …

The mechanisms by which multiple myeloma (MM) cells migrate and home to the bone
marrow are not well understood. In this study, we sought to determine the effect of the …

Multiple myeloma (MM) is a type of B-cell malignancy that remains incurable to date. The
bone marrow (BM) microenvironment plays a crucial role in MM progression. The …

BACKGROUND AND OBJECTIVES. The chemokine receptor CXCR3, involved in
chemotaxis, is expressed on normal and malignant B cells and plasma cells. Recent data …

The chemokine receptor CXCR4 and its ligand stromal cell-derived factor-1 (SDF-
1/CXCL12) are important players in the cross-talk among lymphoma, myeloma and …

Tumor cells are known to adapt to and utilize existing physiological mechanisms to promote
survival and metastasis. The role of the microenvironment in the establishment of a …

Bone sarcomas, which comprise less than 1% of all human malignancies, are a group of
relatively rare mesenchymal-derived tumors. They are mainly composed of osteosarcoma …