Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …

Synthetic and anti-cancer activity aspects of 1, 3, 4-thiadiazole containing bioactive molecules: A concise review

VA Obakachi, B Kushwaha, ND Kushwaha… - Journal of Sulfur …, 2021 - Taylor & Francis
Despite significant advances in understanding cancer pathogenesis, it continues to be one
of the leading causes of death. Thus, there is an urgent need for the development of novel …

[HTML][HTML] A review: Medicinally important nitrogen sulphur containing heterocycles

PK Sharma, A Amin, M Kumar - The Open Medicinal Chemistry …, 2020 - benthamopen.com
Nitrogen sulphur containing heterocycles have specific properties due to which they can be
used as a potential material in a different type of industries such as medicinal …

Sulfur containing scaffolds in drugs: synthesis and application in medicinal chemistry

M Feng, B Tang, SH Liang… - Current topics in medicinal …, 2016 - ingentaconnect.com
The impact of the development of sulfur therapeutics is instrumental to the evolution of the
pharmaceutical industry. Sulfur-derived functional groups can be found in a broad range of …

The importance of sulfur-containing motifs in drug design and discovery

M Mustafa, JY Winum - Expert opinion on drug discovery, 2022 - Taylor & Francis
Introduction Sulfur-containing functional groups are privileged motifs that occur in various
pharmacologically effective substances and several natural products. Various functionalities …

Disulfide and multisulfide antitumor agents and their modes of action

SH Lee - Archives of pharmacal research, 2009 - Springer
A variety of natural products that contain disulfide or multisulfide bonds were found to
display potent biological activities, including antitumor activities. At the center of these …

Role of sulphur-heterocycles in medicinal chemistry: An update

S Pathania, RK Narang, RK Rawal - European journal of medicinal …, 2019 - Elsevier
From many decades, S-heterocycles have maintained their status as an important part and
core of FDA approved drugs and medicinally active compounds. With exhaustive exploration …

Thiazole in the targeted anticancer drug discovery

A Ayati, S Emami, S Moghimi… - Future medicinal …, 2019 - Taylor & Francis
Cancer is known as one of the main causes of death in the world; and many compounds
have been synthesized to date with potential use in cancer therapy. Thiazole is a versatile …

Thiophene-based derivatives as anticancer agents: An overview on decade's work

S Pathania, PA Chawla - Bioorganic Chemistry, 2020 - Elsevier
Heterocyclic compounds hold a pivotal place in medicinal chemistry due to their wide range
of biological activities and thus, are exhaustively explored in the field of drug design and …

[HTML][HTML] Thiadiazines, N,N-Heterocycles of Biological Relevance

H Rodríguez, M Suárez, F Albericio - Molecules, 2012 - mdpi.com
The 3, 5-disubstituted tetrahydro-2 H-1, 3, 5-thiadiazine-2-thione scaffold has found many
applications in recent years. This review is aimed at highlighting the most important aspects …