Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells

I Rosová, M Dao, B Capoccia, D Link, JA Nolta - Stem cells, 2008 - academic.oup.com
Mesenchymal stem cells (MSC) are adult multipotent cells found in bone marrow, adipose
tissue, and other adult tissues. MSC have been shown to improve regeneration of injured …

Human bone marrow-derived mesenchymal stem cells display enhanced clonogenicity but impaired differentiation with hypoxic preconditioning

LB Boyette, OA Creasey, L Guzik… - Stem cells …, 2014 - academic.oup.com
Stem cells are promising candidate cells for regenerative applications because they
possess high proliferative capacity and the potential to differentiate into other cell types …

Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells

B Antebi, LA Rodriguez, KP Walker, AM Asher… - Stem Cell Research & …, 2018 - Springer
Background In the bone marrow, MSCs reside in a hypoxic milieu (1–5% O 2) that is thought
to preserve their multipotent state. Typically, in vitro expansion of MSCs is performed under …

Hypoxia preconditioned human adipose derived mesenchymal stem cells enhance angiogenic potential via secretion of increased VEGF and bFGF

L Liu, J Gao, Y Yuan, Q Chang, Y Liao… - Cell biology …, 2013 - Wiley Online Library
Mesenchymal stem cells (MSCs) are adult multipotent cells found in bone marrow, adipose
tissue, and other adult tissues. MSCs improve regeneration of injured tissues in vivo, but the …

Hypoxic preconditioning of mesenchymal stromal cells induces metabolic changes, enhances survival, and promotes cell retention in vivo

J Beegle, K Lakatos, S Kalomoiris, H Stewart… - Stem …, 2015 - academic.oup.com
Mesenchymal stem cells/multipotent stromal cells (MSCs) are promising therapeutics for a
variety of conditions. However, after transplantation, cell retention remains extremely …

The role of hypoxia in bone marrow–derived mesenchymal stem cells: considerations for regenerative medicine approaches

R Das, H Jahr, GJVM van Osch… - Tissue Engineering Part B …, 2010 - liebertpub.com
Bone marrow–derived mesenchymal stem cells (MSCs) have demonstrated potential for
regenerative medicine strategies. Knowledge of the way these cells respond to their …

Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status

L Basciano, C Nemos, B Foliguet, N de Isla… - BMC cell biology, 2011 - Springer
Background In the bone marrow, hematopietic and mesenchymal stem cells form a unique
niche in which the oxygen tension is low. Hypoxia may have a role in maintaining stem cell …

Hypoxic preconditioning of mesenchymal stem cells with subsequent spheroid formation accelerates repair of segmental bone defects

SS Ho, BP Hung, N Heyrani, MA Lee, JK Leach - Stem Cells, 2018 - academic.oup.com
Cell-based approaches for musculoskeletal tissue repair are limited by poor cell survival
and engraftment. Short-term hypoxic preconditioning of mesenchymal stem cells (MSCs) …

Hypoxia preconditioned mesenchymal stem cells improve vascular and skeletal muscle fiber regeneration after ischemia through a Wnt4-dependent pathway

L Leroux, B Descamps, NF Tojais, B Séguy, P Oses… - Molecular therapy, 2010 - cell.com
Mesenchymal stem cells (MSC) are multipotent postnatal stem cells, involved in the
treatment of ischemic vascular diseases. We investigate the ability of MSC, exposed to short …

Hypoxia-conditioned mesenchymal stem cells in tissue regeneration application

Y Yang, EH Lee, Z Yang - Tissue Engineering Part B: Reviews, 2022 - liebertpub.com
Mesenchymal stem cells (MSCs) have been demonstrated as promising cell sources for
tissue regeneration due to their capability of self-regeneration, differentiation, and …